NAD+ degrading enzymes, evidence for roles during infection

Tan, A. and Doig, C.L. ORCID: 0000-0001-9694-4230, 2021. NAD+ degrading enzymes, evidence for roles during infection. Frontiers in Molecular Biosciences, 8: 697359.

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Declines in cellular nicotinamide adenine dinucleotide (NAD) contribute to metabolic dysfunction, increase susceptibility to disease, and occur as a result of pathogenic infection. The enzymatic cleavage of NAD+ transfers ADP-ribose (ADPr) to substrate proteins generating mono-ADP-ribose (MAR), poly-ADP-ribose (PAR) or O-acetyl-ADP-ribose (OAADPr). These important post-translational modifications have roles in both immune response activation and the advancement of infection. In particular, emergent data show viral infection stimulates activation of poly (ADP-ribose) polymerase (PARP) mediated NAD+ depletion and stimulates hydrolysis of existing ADP-ribosylation modifications. These studies are important for us to better understand the value of NAD+ maintenance upon the biology of infection. This review focuses specifically upon the NAD+ utilising enzymes, discusses existing knowledge surrounding their roles in infection, their NAD+ depletion capability and their influence within pathogenic infection.

Item Type: Review
Publication Title: Frontiers in Molecular Biosciences
Creators: Tan, A. and Doig, C.L.
Publisher: Frontiers Media SA
Date: 16 August 2021
Volume: 8
Rights: Copyright © 2021 Tan and Doig. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Divisions: Schools > School of Science and Technology
Record created by: Linda Sullivan
Date Added: 04 Nov 2021 10:41
Last Modified: 04 Nov 2021 10:41

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