An appetite for growth: the role of the hypothalamic–pituitary–growth hormone axis in energy balance

Dumbell, R. ORCID: 0000-0002-8805-3777, 2022. An appetite for growth: the role of the hypothalamic–pituitary–growth hormone axis in energy balance. Journal of Neuroendocrinology: e13133. ISSN 0953-8194

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Links between the regulation of growth and energy balance are clear; to fuel growth, there must be consumption of energy. Therefore, it is perhaps intuitive that interactions between the hypothalamic – pituitary – growth hormone axis (growth axis) and pathways that drive metabolic processes exist. Overproduction of growth hormone has been associated with diabetes and metabolic disease for decades and the opposing effects of growth hormone and insulin have been studied since early experiments almost a century ago. The relationship between neuroendocrine axes can be complex and the growth axis is no exception, interacting with energy balance in several organ systems, both in the periphery and centrally in hypothalamic nuclei. Much is known about peripheral interactions between growth axis hormones and processes such as glucose homeostasis and adipogenesis. More is still being learned about the molecular actions of growth axis hormones in adipose and other metabolically active tissues, and recent findings are discussed in this perspective. However, less is known about interactions with central energy balance pathways in the hypothalamus. This perspective aims to summarise what is known about these interactions, taking lessons from human studies and animal genetic and seasonal models, and discusses what this may mean in an evolving landscape of personalised medicine.

Item Type: Journal article
Publication Title: Journal of Neuroendocrinology
Creators: Dumbell, R.
Publisher: Wiley
Date: 30 March 2022
ISSN: 0953-8194
Rights: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2022 The Author. Journal of Neuroendocrinology published by John Wiley & Sons Ltd on behalf of British Society for Neuroendocrinology.
Divisions: Schools > School of Science and Technology
Record created by: Laura Ward
Date Added: 21 Apr 2022 14:52
Last Modified: 27 Apr 2022 14:29

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