A dominant set-informed interpretable fuzzy system for automated diagnosis of dementia

Chen, T., Su, P., Shen, Y., Chen, L., Mahmud, M. ORCID: 0000-0002-2037-8348, Zhao, Y. and Antoniou, G., 2022. A dominant set-informed interpretable fuzzy system for automated diagnosis of dementia. Frontiers in Neuroscience, 16: 867664. ISSN 1662-4548

1597199_Mahmud.pdf - Published version

Download (2MB) | Preview


Dementia is an incurable neurodegenerative disease primarily affecting the older population, for which the World Health Organisation has set to promoting early diagnosis and timely management as one of the primary goals for dementia care. While a range of popular machine learning algorithms and their variants have been applied for dementia diagnosis, fuzzy systems, which have been known effective in dealing with uncertainty and offer to explicitly reason how a diagnosis can be inferred, sporadically appear in recent literature. Given the advantages of a fuzzy rule-based model, which could potentially result in a clinical decision support system that offers understandable rules and a transparent inference process to support dementia diagnosis, this paper proposes a novel fuzzy inference system by adapting the concept of dominant sets that arise from the study of graph theory. A peeling-off strategy is used to iteratively extract from the constructed edge-weighted graph a collection of dominant sets. Each dominant set is further converted into a parameterized fuzzy rule, which is finally optimized in a supervised adaptive network-based fuzzy inference framework. An illustrative example is provided that demonstrates the interpretable rules and the transparent reasoning process of reaching a decision. Further systematic experiments conducted on data from the Open Access Series of Imaging Studies (OASIS) repository, also validate its superior performance over alternative methods.

Item Type: Journal article
Publication Title: Frontiers in Neuroscience
Creators: Chen, T., Su, P., Shen, Y., Chen, L., Mahmud, M., Zhao, Y. and Antoniou, G.
Publisher: Frontiers Media SA
Date: 2022
Volume: 16
ISSN: 1662-4548
Rights: Copyright © 2022 Chen, Su, Shen, Chen, Mahmud, Zhao and Antoniou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Divisions: Schools > School of Science and Technology
Record created by: Linda Sullivan
Date Added: 13 Sep 2022 09:12
Last Modified: 13 Sep 2022 09:15
URI: https://irep.ntu.ac.uk/id/eprint/47019

Actions (login required)

Edit View Edit View


Views per month over past year


Downloads per month over past year