Microfluidics meets layer-by-layer assembly for the build-up of polymeric scaffolds

Yola, A.M., Campbell, J. ORCID: 0000-0002-3374-9240 and Volodkin, D. ORCID: 0000-0001-7474-5329, 2021. Microfluidics meets layer-by-layer assembly for the build-up of polymeric scaffolds. Applied Surface Science Advances, 5: 100091.

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The Layer-by-Layer (LbL) assembly of polymers and microfluidics belong to a category of the most useful and promising techniques emerged within the last three-to-four decades. Despite the high promise to combine LbL deposition with microfluidic techniques for the formulation of polymeric scaffolds, this combination is limited thus far, and is only presented by few literature reports only. This combination holds the ability to aid in assembling advanced scaffolds with programmable and highly controlled properties. Here we highlight the advantages and disadvantages for both LbL assembly onto 2D and 3D substrates, and of microfluidic techniques observed in the literature thus far. Firstly, LbL assembly is presented, focusing upon its basic principles, hard-templating and multilayer capsule formation, followed by deposition technical aspects. The basics of microfluidics is described in view of the formulation of polymer structures, whereby examples of microfluidic-assisted scaffold fabrication via LbL assembly are provided. This review seeks to provide the reader with a critical view on the application of microfluidic techniques, in combination with LbL assembly for the production of polymer scaffolds.

Item Type: Journal article
Publication Title: Applied Surface Science Advances
Creators: Yola, A.M., Campbell, J. and Volodkin, D.
Publisher: Elsevier BV
Date: September 2021
Volume: 5
S2666523921000374Publisher Item Identifier
Rights: © 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Divisions: Schools > School of Science and Technology
Record created by: Linda Sullivan
Date Added: 16 Nov 2022 11:05
Last Modified: 13 Feb 2024 09:17
URI: https://irep.ntu.ac.uk/id/eprint/47416

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