The serum complement in bone repair; between the norm and flaw

El-Jawhari, J.J. ORCID: 0000-0002-0580-4492, Youssif Ali, M., El-Sherbiny Badawy, Y. ORCID: 0000-0003-4791-3475, Jones, E. and Giannoudis, P., 2021. The serum complement in bone repair; between the norm and flaw. In: 6th European Congress of Immunology, [virtual], 1-4 September 2021.

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The complement system is involved in repairing various tissues, particularly in response to the damage signals. The role of complement in bone repair is limitedly known and mainly based on the findings in other tissues or experimental studies. Here, the complement system was investigated in human sera to assess its involvement during normal bone repair. Additionally, the circulatory levels of the complement system was investigated in complicated bone repair. The serum samples from patients with normally healed long bone fractures were collected at three different time points covering the course of healing. Additionally, serum samples from patients diagnosed with non‐union of long bone fractures and healthy controls were included in the analysis. The complement proteins, initiating factors, and products in serum samples were tested using mass spectrometry and ELISA. The data suggest an involvement/activation of the classic and lytic complement pathways during the early phase of normal bone repair. In contrast, the lectin pathway seemed disengaged in normal repair and highly expressed in the non‐union cases. These data suggest distinctive roles for complement pathway during normal bone repair, and the lectin pathway might be linked to the complicated bone repair. Ongoing work is aiming to explain the complement‐related molecular mechanisms, particularly those associated with abnormal bone healing. Such knowledge will help to understand better the immune response to bone damage in normal versus abnormal bone repair conditions and could potentially help to identify new targets for optimised regenerative therapies

Item Type: Conference contribution
Creators: El-Jawhari, J.J., Youssif Ali, M., El-Sherbiny Badawy, Y., Jones, E. and Giannoudis, P.
Date: September 2021
Divisions: Schools > School of Science and Technology
Record created by: Jeremy Silvester
Date Added: 19 Jan 2023 14:11
Last Modified: 19 Jan 2023 14:11

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