Endotoxemia, vitamin D and premature biological ageing in Arab adults with different metabolic states

Al-Daghri, NM, Sabico, S, Ansari, MGA, Abdi, S, Tripathi, G, Chrousos, GP and McTernan, PG ORCID: https://orcid.org/0000-0001-9023-0261, 2022. Endotoxemia, vitamin D and premature biological ageing in Arab adults with different metabolic states. Saudi Journal of Biological Sciences, 29 (6): 103276. ISSN 1319-562X

Full text not available from this repository.

Abstract

There are limited studies on the association of endotoxin, a potent mediator of gut-derived inflammation and telomere length (TL). We investigated (1) the influence of adiposity on endotoxin and TL amongst Saudi adults according to type 2 diabetes mellitus (T2DM) status and (2) the influence vitamin D may have on TL attrition. Anthropometric data and fasting blood samples were taken from 775 Saudi adults visiting different primary care centers in Riyadh [387 T2DM and 388 non-T2DM]. TL, derived from peripheral blood mononuclear cells, was analyzed by Quantitative real-time polymerase chain reaction and circulating endotoxin levels by Limulus Amebocyte Lysate assay. Subjects were stratified based on obesity and T2DM status. A significant lower TL was observed in the non-obese T2DM group as compared with their non-obese, non-T2DM counterparts (p = 0.002). Significant inverse associations between TL, endotoxin and endotoxin activity were observed in the cohort with obesity. Regression analysis showed that endotoxin was a significant predictor for TL in all subjects and even after stratification according to subgroups; with variances perceived in circulating TL stronger among non-T2DM obese (10%; p = 0.003) than non-T2DM non-obese (12%; p = 0.007). Also, in the non-T2DM group, TL and HDL-cholesterol predicted 29% of the variances perceived in 25(OH)D (p < 0.001). Taken together these findings show that circulating endotoxin and 25(OH)D are associated with premature biological ageing influenced by adiposity and metabolic state; suggesting future intervention studies to manipulate gut microbiome and or vitamin D levels may offer ways to mitigate premature TL attrition.

Item Type:	Journal article
Alternative Title:	Endotoxin induced telomere length attrition
Publication Title:	Saudi Journal of Biological Sciences
Creators:	Al-Daghri, N.M., Sabico, S., Ansari, M.G.A., Abdi, S., Tripathi, G., Chrousos, G.P. and McTernan, P.G.
Publisher:	Elsevier
Date:	June 2022
Volume:	29
Number:	6
ISSN:	1319-562X
Identifiers:	Number Type 10.1016/j.sjbs.2022.03.026 DOI S1319562X2200184X Publisher Item Identifier 1733303 Other
Rights:	This is an open access article under the CC BY license http://creativecommons.org/licenses/by/4.0/).
Divisions:	Schools > School of Science and Technology
Record created by:	Jonathan Gallacher
Date Added:	16 Feb 2023 17:41
Last Modified:	16 Feb 2023 17:41
URI:	https://irep.ntu.ac.uk/id/eprint/48328

Actions (login required)

Edit View

Statistics

Views

Downloads