Excitation-inhibition imbalance in migraine: from neurotransmitters to brain oscillations

O'Hare, L. ORCID: 0000-0003-0331-3646, Tarasi, L., Asher, J.M., Hibbard, P.B. and Romei, V., 2023. Excitation-inhibition imbalance in migraine: from neurotransmitters to brain oscillations. International Journal of Molecular Sciences, 24 (12): 10093. ISSN 1661-6596

1771319_O_Hare.pdf - Published version

Download (2MB) | Preview


Migraine is among the most common and debilitating neurological disorders typically affecting people of working age. It is characterised by a unilateral, pulsating headache often associated with severe pain. Despite the intensive research, there is still little understanding of the pathophysiology of migraine. At the electrophysiological level, altered oscillatory parameters have been reported within the alpha and gamma bands. At the molecular level, altered glutamate and GABA concentrations have been reported. However, there has been little cross-talk between these lines of research. Thus, the relationship between oscillatory activity and neurotransmitter concentrations remains to be empirically traced. Importantly, how these indices link back to altered sensory processing has to be clearly established as yet. Accordingly, pharmacologic treatments have been mostly symptom-based, and yet sometimes proving ineffective in resolving pain or related issues. This review provides an integrative theoretical framework of excitation-inhibition imbalance for the understanding of current evidence and to address outstanding questions concerning the pathophysiology of migraine. We propose the use of computational modelling for the rigorous formulation of testable hypotheses on mechanisms of homeostatic imbalance and for the development of mechanism-based pharmacological treatments and neurostimulation interventions.

Item Type: Journal article
Publication Title: International Journal of Molecular Sciences
Creators: O'Hare, L., Tarasi, L., Asher, J.M., Hibbard, P.B. and Romei, V.
Publisher: MDPI
Date: 13 June 2023
Volume: 24
Number: 12
ISSN: 1661-6596
Rights: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Divisions: Schools > School of Social Sciences
Record created by: Jonathan Gallacher
Date Added: 19 Jun 2023 15:23
Last Modified: 19 Jun 2023 15:23
URI: https://irep.ntu.ac.uk/id/eprint/49223

Actions (login required)

Edit View Edit View


Views per month over past year


Downloads per month over past year