Shift work-like patterns effect on female and male mouse behavior

Banks, G. ORCID: 0000-0002-8647-667X, Nolan, P.M. and Bourbia, N., 2022. Shift work-like patterns effect on female and male mouse behavior. Neurobiology of Sleep and Circadian Rhythms, 13: 100082.

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Shift work (work outside of standard daylight hours) is common throughout the Western world. However, there are notable health consequences to shift work, including increased prevalence of mental health and sleep disorders in shift worker populations. Therefore, the health and wellbeing of shift workers is a public health concern that needs to be addressed. Here we investigate the effects of two separate light induced shift work-like patterns on male and female mouse behaviour (anxiety-like, exploration, marble burying, startle reflex and circadian rhythms). After 6 weeks of shift-like disruptions patterns, animals displayed no behavioral differences in exploration, marble burying and startle reflex. Interestingly however, we identified sex specific and disruption specific effects in light aversion and wheel running activities. Notably, analysis of the activity patterns of animals in disruptive conditions demonstrated that they maintained a degree of rhythmicity through the disruption period, which may explain the lack of behavioral differences in most behavioral tests.

Item Type: Journal article
Publication Title: Neurobiology of Sleep and Circadian Rhythms
Creators: Banks, G., Nolan, P.M. and Bourbia, N.
Publisher: Elsevier BV
Date: November 2022
Volume: 13
S245199442200008Publisher Item Identifier
Rights: Copyright: © 2022 The Authors. Published by Elsevier Inc. Open access article distributed under the terms of the Creative Commons CC-BY license.
Divisions: Schools > School of Science and Technology
Record created by: Linda Sullivan
Date Added: 19 Jul 2023 09:40
Last Modified: 19 Jul 2023 09:40

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