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Džidić-Krivić, A., Kusturica, J., Sher, E.K., Selak, N., Osmančević, N., Karahmet Farhat, E. and Sher, F. 
ORCID: 0000-0003-2890-5912,
2023.
Effects of intestinal flora on pharmacokinetics and pharmacodynamics of drugs.
Drug Metabolism Reviews, 55 (1-2), pp. 126-139.
ISSN 0360-2532
Abstract
Gut microbiota is known as unique collection of microorganisms (including bacteria, archaea, eukaryotes and viruses) that exist in a complex environment of the gut. Recently, this has become one of the most popular areas of research in medicine because this plays not only an important role in disease development, but gut microbiota also influences drug pharmacokinetics. These alterations in drug pharmacokinetic pathways and drug concentration in plasma and blood often lead to an increase in the incidence of toxicological events in patients. This review aims to present current knowledge of the most commonly used drugs in clinical practice and their dynamic interplay with the host’s gut microbiota as well as the mechanisms underlying these metabolic processes and the consequent effect on their therapeutic efficacy and safety. These new findings set a foundation for the development of personalized treatments specific to each metabolism, maximizing drugs’ therapeutic effects and minimizing the side effects because they are one of the major limiting factors in treating patients.
| Item Type: | Journal article | ||||||
|---|---|---|---|---|---|---|---|
| Publication Title: | Drug Metabolism Reviews | ||||||
| Creators: | Džidić-Krivić, A., Kusturica, J., Sher, E.K., Selak, N., Osmančević, N., Karahmet Farhat, E. and Sher, F. | ||||||
| Publisher: | Taylor & Francis | ||||||
| Date: | 2023 | ||||||
| Volume: | 55 | ||||||
| Number: | 1-2 | ||||||
| ISSN: | 0360-2532 | ||||||
| Identifiers: |
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| Rights: | This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/),which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in anyway. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. | ||||||
| Divisions: | Schools > School of Science and Technology | ||||||
| Record created by: | Jonathan Gallacher | ||||||
| Date Added: | 01 Nov 2023 15:27 | ||||||
| Last Modified: | 01 Nov 2023 15:27 | ||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/50203 |
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