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Campbell, J., Ferreira, A.M., Bowker, L., Hunt, J. 
ORCID: 0000-0002-5168-4778, Volodkin, D. ORCID: 0000-0001-7474-5329 and Vikulina, A. ORCID: 0000-0001-9427-2055,
2022.
Dextran and its derivatives: biopolymer additives for the modulation of vaterite CacCO3 crystal morphology and adhesion to cells.
Advanced Materials Interfaces, 9 (31): 2201196.
ISSN 2196-7350
Abstract
Nowadays, a great demand for the development of novel drug delivery systems with high potential for bench-to-market transition attracts scientific attention toward materials that are already approved for biomedical use. Here, controlled fabrication of hybrid organic inorganic mesoporous crystals is realized in physiologically relevant conditions by co-synthesis of vaterite CaCO3 in the presence of dextran (DEX) or its functional derivatives. The effects of DEX molecular weight and chemical structure on morphology, porosity, and stability of the hybrids are investigated. Molecular weight of DEX does not affect the crystal growth but leads to the partial blocking of crystal pores. Co-synthesis of DEX functionalized with either carboxymethyl (CM) or diethylaminoethyl (DEAE) groups drastically increased crystal porosity without influencing crystal size. pH-dependent vaterite-to-calcite recrystallization is significantly suppressed by inclusion of carboxymethyl-dextran (CM-DEX), making vaterite crystals stable in acidic medium, whereas the incorporation of diethylaminoethyl-dextran (DEAE-DEX) has no effect. The hybrids prepared with charged DEX derivatives possess stronger adhesion to normal human dermal fibroblasts: three times higher crystal adherence compared to pristine crystals. These results provide fundamental physical–chemical insights into the crystallization of DEX/vaterite hybrids and are discussed in view of the potential of these functional delivery carriers for biomedical and other applications.
| Item Type: | Journal article | ||||||
|---|---|---|---|---|---|---|---|
| Publication Title: | Advanced Materials Interfaces | ||||||
| Creators: | Campbell, J., Ferreira, A.M., Bowker, L., Hunt, J., Volodkin, D. and Vikulina, A. | ||||||
| Publisher: | Wiley | ||||||
| Date: | November 2022 | ||||||
| Volume: | 9 | ||||||
| Number: | 31 | ||||||
| ISSN: | 2196-7350 | ||||||
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| Rights: | This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | ||||||
| Divisions: | Schools > School of Science and Technology | ||||||
| Record created by: | Jonathan Gallacher | ||||||
| Date Added: | 13 Feb 2024 08:49 | ||||||
| Last Modified: | 13 Feb 2024 08:49 | ||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/50848 |
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