Tools
Tools
Cui, Y., Ying, C. 
ORCID: 0000-0002-7279-1388, Huang, X.-Y., Ye, Q., Tian, J. and Liu, Z.,
2024.
Electrical transport and dynamics of confined DNA through highly conductive 2D graphene nanochannels.
Nano Letters.
ISSN 1530-6984
![[img]](/style/images/fileicons/text.png) |
Text
1883122_Ying.pdf - Post-print Full-text access embargoed until 5 April 2025. Download (1MB) |
Abstract
Confining DNA in nanochannels is an important approach to studying its structure and transportation dynamics. Graphene nanochannels are particularly attractive for studying DNA confinement due to their atomic flatness, precise height control, and excellent mechanical strength. Here, using femtosecond laser etching and wetting transfer, we fabricate graphene nanochannels down to less than 4.3 nm in height, with the length-to-height ratios up to 103. These channels exhibit high stability, low noise, and self-cleaning ability during the long-term ionic current recording. We report a clear linear relationship between DNA length and the residence time in the channel and further utilize this relationship to differentiate DNA fragments based on their lengths, ranging widely from 200 bps to 48.5 kbps. The graphene nanochannel presented here provides a potential platform for label-free analyses and reveals fundamental insights into the conformational dynamics of DNA and proteins in confined space.
| Item Type: | Journal article | ||||||
|---|---|---|---|---|---|---|---|
| Publication Title: | Nano Letters | ||||||
| Creators: | Cui, Y., Ying, C., Huang, X.-Y., Ye, Q., Tian, J. and Liu, Z. | ||||||
| Publisher: | American Chemical Society | ||||||
| Date: | 5 April 2024 | ||||||
| ISSN: | 1530-6984 | ||||||
| Identifiers: |
|
||||||
| Rights: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Nano Letters, copyright © 2024 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see: https://doi.org/10.1021/acs.nanolett.4c00403 | ||||||
| Divisions: | Schools > School of Science and Technology | ||||||
| Record created by: | Jonathan Gallacher | ||||||
| Date Added: | 09 Apr 2024 15:04 | ||||||
| Last Modified: | 10 Apr 2024 07:28 | ||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/51222 |
Actions (login required)
 |
Edit View |
Views
Views per month over past year
Downloads
Downloads per month over past year
