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Windels, EM, Agüí, CV, de Jong, BC, Meehan, CJ 
ORCID: https://orcid.org/0000-0003-0724-8343, Loiseau, C, Goig, GA, Zwyer, M, Borrell, S, Brites, D, Gagneux, S and Stadler, T,
2025.
Onset of infectiousness explains differences in transmissibility across Mycobacterium tuberculosis lineages.
Epidemics, 51: 100821.
ISSN 1755-4365
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Abstract
Mycobacterium tuberculosis complex (MTBC) lineages show substantial variability in virulence, but the epidemiological consequences of this variability have not been studied in detail. Here, we aimed for a lineage-specific epidemiological characterization by applying phylodynamic models to genomic data from different countries, representing the most abundant MTBC lineages. Our results suggest that all lineages are associated with similar durations and levels of infectiousness, resulting in similar reproductive numbers. However, L1 and L6 are associated with a delayed onset of infectiousness, leading to longer periods between subsequent transmission events. Together, our findings highlight the role of MTBC genetic diversity in tuberculosis disease progression and transmission.
| Item Type: | Journal article |
|---|---|
| Publication Title: | Epidemics |
| Creators: | Windels, E.M., Agüí, C.V., de Jong, B.C., Meehan, C.J., Loiseau, C., Goig, G.A., Zwyer, M., Borrell, S., Brites, D., Gagneux, S. and Stadler, T. |
| Publisher: | Elsevier BV |
| Date: | June 2025 |
| Volume: | 51 |
| ISSN: | 1755-4365 |
| Identifiers: | Number Type 10.1016/j.epidem.2025.100821 DOI S175543652500009X Publisher Item Identifier 2405976 Other |
| Rights: | © 2025 The Author(s). Published by Elsevier B.V. This is an open access article distributed under the terms of the Creative Commons CC-BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Divisions: | Schools > School of Science and Technology |
| Record created by: | Melissa Cornwell |
| Date Added: | 25 Mar 2025 09:53 |
| Last Modified: | 25 Mar 2025 09:53 |
| URI: | https://irep.ntu.ac.uk/id/eprint/53294 |
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