Sialic acid utilization by Cronobacter sakazakii

Joseph, S., Hariri, S., Masood, N. and Forsythe, S. ORCID: 0000-0002-6709-0712, 2013. Sialic acid utilization by Cronobacter sakazakii. Microbial Informatics and Experimentation, 3 (3). ISSN 2042-5783

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Background: The Cronobacter genus is composed of seven species, and can cause infections in all age groups. Of particular concern is C. sakazakii, as this species is strongly associated with severe and often fatal cases of necrotizing enterocolitis and meningitis in neonates and infants. Whole genome sequencing has revealed that the nanAKT gene cluster required for the utilisation of exogenous sialic acid is unique to the C. sakazakii species (ESA_03609-13). Sialic acid is found in breast milk, infant formula, intestinal mucin, and gangliosides in the brain, hence its metabolism by C. sakazakii is of particular interest. Therefore its metabolism could be an important virulence factor. To date, no laboratory studies demonstrating the growth of C. sakazakii on sialic acid have been published nor have there been reports of sialidase activity. The phylogenetic analysis of the nan genes is of interest to determine whether the genes have been acquired by horizontal gene transfer.

Item Type: Journal article
Publication Title: Microbial Informatics and Experimentation
Creators: Joseph, S., Hariri, S., Masood, N. and Forsythe, S.
Publisher: BioMed Central
Place of Publication: London
Date: 2013
Volume: 3
Number: 3
ISSN: 2042-5783
Rights: © 2013 Joseph et al.; licensee BioMed Central Ltd.
Divisions: Schools > School of Science and Technology
Record created by: EPrints Services
Date Added: 09 Oct 2015 10:06
Last Modified: 09 Jun 2017 13:19

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