Evaluation of the cytotoxic and genotoxic potential of Khat (Catha edulis Forsk) extracts on human T lymphoblastoid cell line

Barkwan, S.S., Barnett, C.R., Barnett, Y.A., Tompkins, P.T. and Fokunang, C.N., 2004. Evaluation of the cytotoxic and genotoxic potential of Khat (Catha edulis Forsk) extracts on human T lymphoblastoid cell line. Journal of Medical Sciences, 4 (2), pp. 110-114. ISSN 1682-4474

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Abstract

This paper reports on an investigation of the cytotoxic and genotoxic potential of khat extract using a human T lymphoblastoid cell line (CEM). Exponentially growing CEM cells were cultured for 12 h in the presence of khat extract (0-2000 μg ml-1). Statistically significant, dose-dependent increases in; CEM cell death at dose (> 400 μg ml-1), in DNA damage at dose (>200 μg ml-1) and in micronuclei frequency, at dose (>200 μg ml-1) were observed. The genetic damage effects of khat extract on human cell line observed in this study could serve as a major contribution towards the understanding and creating of awareness of an increased risk of cancer amongst long-term khat consumers.

Item Type:	Journal article
Publication Title:	Journal of Medical Sciences
Creators:	Barkwan, S.S., Barnett, C.R., Barnett, Y.A., Tompkins, P.T. and Fokunang, C.N.
Publisher:	Asian Network for Scientific Information
Date:	2004
Volume:	4
Number:	2
ISSN:	1682-4474
Identifiers:	Number Type 10.3923/jms.2004.110.114 DOI
Divisions:	Schools > School of Science and Technology
Record created by:	EPrints Services
Date Added:	09 Oct 2015 10:07
Last Modified:	23 Aug 2016 09:08
URI:	https://irep.ntu.ac.uk/id/eprint/8169

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