Barkwan, SS, Barnett, CR, Barnett, YA, Tompkins, PT and Fokunang, CN, 2004. Evaluation of the cytotoxic and genotoxic potential of Khat (Catha edulis Forsk) extracts on human T lymphoblastoid cell line. Journal of Medical Sciences, 4 (2), pp. 110-114. ISSN 1682-4474
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Abstract
This paper reports on an investigation of the cytotoxic and genotoxic potential of khat extract using a human T lymphoblastoid cell line (CEM). Exponentially growing CEM cells were cultured for 12 h in the presence of khat extract (0-2000 μg ml-1). Statistically significant, dose-dependent increases in; CEM cell death at dose (> 400 μg ml-1), in DNA damage at dose (>200 μg ml-1) and in micronuclei frequency, at dose (>200 μg ml-1) were observed. The genetic damage effects of khat extract on human cell line observed in this study could serve as a major contribution towards the understanding and creating of awareness of an increased risk of cancer amongst long-term khat consumers.
Item Type: | Journal article |
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Publication Title: | Journal of Medical Sciences |
Creators: | Barkwan, S.S., Barnett, C.R., Barnett, Y.A., Tompkins, P.T. and Fokunang, C.N. |
Publisher: | Asian Network for Scientific Information |
Date: | 2004 |
Volume: | 4 |
Number: | 2 |
ISSN: | 1682-4474 |
Identifiers: | Number Type 10.3923/jms.2004.110.114 DOI |
Divisions: | Schools > School of Science and Technology |
Record created by: | EPrints Services |
Date Added: | 09 Oct 2015 10:07 |
Last Modified: | 23 Aug 2016 09:08 |
URI: | https://irep.ntu.ac.uk/id/eprint/8169 |
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