Items where Author is "Hardy, RS"

CRASTIN, A., SHANKER, A., SAGMEISTER, M.S., TAYLOR, A., LAVERY, G.G., RAZA, K. and HARDY, R.S., 2025. Vamorolone: a novel metabolism resistant steroid that suppresses joint destruction in chronic polyarthritis with reduced systemic side effects. Rheumatology, 64 (7), pp. 4371-4381. ISSN 1462-0332

HEASELGRAVE, S.R., HEISING, S., MORGAN, S.A., CARTHWRIGHT, D.M., SAGMEISTER, M., HARDY, R.S., DOIG, C.L., MORTON, N.M., TSINTZAS, K. and LAVERY, G.G., 2024. Glucocorticoid excess alters metabolic rate and substrate utilisation via 11β-HSD1. Journal of Endocrinology, 263 (2): e240205. ISSN 0022-0795

WEBSTER, J.M., WAAIJENBERG, K., VAN DE WORP, W.R.P.H., KELDERS, M.C.J.M., LAMBRICHTS, S., MARTIN, C., VERHAEGEN, F., VAN DER HEYDEN, B., SMITH, C., LAVERY, G.G., SCHOLS, A.M.W.J., HARDY, R.S. and LANGEN, R.C.J., 2023. 11β-HSD1 determines the extent of muscle atrophy in a model of acute exacerbation of COPD. AJP - Lung Cellular and Molecular Physiology, 324 (4), L400-L412. ISSN 1040-0605

MERK, V.M., PHAN, T.S., WIEDMANN, A., HARDY, R.S., LAVERY, G.G. and BRUNNER, T., 2023. Local glucocorticoid synthesis regulates house dust mite-induced airway hypersensitivity in mice. Frontiers in Immunology, 14: 1252874. ISSN 1664-3224

WEBSTER, J.M., SAGMEISTER, M.S., FENTON, C.G., SEABRIGHT, A.P., LAI, Y.-C., JONES, S.W., FILER, A., COOPER, M.S., LAVERY, G.G., RAZA, K., LANGEN, R. and HARDY, R.S., 2021. Global Deletion of 11β-HSD1 prevents muscle wasting associated with glucocorticoid therapy in polyarthritis. International Journal of Molecular Sciences, 22 (15): 7828. ISSN 1661-6596

FENTON, C., MARTIN, C., JONES, R., CROFT, A., CAMPOS, J., NAYLOR, A.J., TAYLOR, A.E., CHIMEN, M., COOPER, M., LAVERY, G.G., RAZA, K. and HARDY, R.S., 2021. Local steroid activation is a critical mediator of the anti-inflammatory actions of therapeutic glucocorticoids. Annals of the Rheumatic Diseases, 80 (2), pp. 250-260. ISSN 0003-4967

HARDY, R.S., BOTFIELD, H., MARKEY, K., MITCHELL, J.L., ALIMAJSTOROVIC, Z., WESTGATE, C.S.J., SAGMEISTER, M., FAIRCLOUGH, R.J., OTTRIDGE, R.S., YIANGOU, A., STORBECK, K.-H.H., TAYLOR, A.E., GILLIGAN, L.C., ARLT, W., STEWART, P.M., TOMLINSON, J.W., MOLLAN, S.P., LAVERY, G.G. and SINCLAIR, A.J., 2021. 11βHSD1 inhibition with AZD4017 improves lipid profiles and lean muscle mass in idiopathic intracranial hypertension. The Journal of Clinical Endocrinology and Metabolism, 106 (1), pp. 174-187. ISSN 0021-972X

MAHIDA, R.Y., SCOTT, A., PAREKH, D., LUGG, S.T., HARDY, R.S., LAVERY, G.G., MATTHAY, M.A., NAIDU, B., PERKINS, G.D. and THICKETT, D.R., 2021. Acute respiratory distress syndrome is associated with impaired alveolar macrophage efferocytosis. European Respiratory Journal, 58 (3): 2100829. ISSN 0903-1936

FENTON, C.G., DOIG, C.L., FAREED, S., NAYLOR, A., MORRELL, A.P., ADDISON, O., WEHMEYER, C., BUCKLEY, C.D., COOPER, M.S., LAVERY, G.G., RAZA, K. and HARDY, R.S., 2019. 11β-HSD1 plays a critical role in trabecular bone loss associated with systemic glucocorticoid therapy. Arthritis Research and Therapy, 21: 188. ISSN 1478-6362

HARDY, R.S., DOIG, C.L., HUSSAIN, Z., O'LEARY, M., MORGAN, S.A., PEARSON, M.J., NAYLOR, A., JONES, S.W., FILER, A., STEWART, P.M., BUCKLEY, C.D., LAVERY, G.G., COOPER, M.S. and RAZA, K., 2016. 11β-Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation. The Journal of Pathology, 240 (4), pp. 472-483. ISSN 0022-3417