Osteoprotegerin, a crucial regulator of bone metabolism, also regulates B cell development and function

Yun, TJ, Tallquist, MD, Aicher, A, Rafferty, KL, Marshall, AJ, Moon, JJ, Ewings, MK, Mohaupt, M, Herring, SW and Clark, EA, 2001. Osteoprotegerin, a crucial regulator of bone metabolism, also regulates B cell development and function. Journal of Immunology, 166 (3), pp. 1482-1491. ISSN 0022-1767

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Osteoprotegerin (OPG) is a CD40-regulated gene in B cells and dendritic cells (DCs). We investigated the role of OPG in the immune system by generating opg-/- mice. Like its role as a regulator of bone metabolism, OPG also influences processes in the immune system, notably in B cell development. Ex vivo, opg-/- pro-B cells have enhanced proliferation to IL-7, and in opg-/- spleen, there is an accumulation of type 1 transitional B cells. Furthermore, opg-/- bone marrow-derived DCs are more effective in stimulating allogeneic T cells than control DCs. When challenged with a T-dependent Ag, opg-/- mice had a compromised ability to sustain an IgG3 Ag-specific response. Thus, in the immune system, OPG regulates B cell maturation and development of efficient Ab responses.

Item Type: Journal article
Publication Title: Journal of Immunology
Creators: Yun, T.J., Tallquist, M.D., Aicher, A., Rafferty, K.L., Marshall, A.J., Moon, J.J., Ewings, M.K., Mohaupt, M., Herring, S.W. and Clark, E.A.
Publisher: American Association of Immunologists
Date: 2001
Volume: 166
Number: 3
ISSN: 0022-1767
Rights: Copyright © 2001 by The American Association of Immunologists, Inc. All rights reserved.
Divisions: Schools > School of Science and Technology
Depositing User: EPrints Services
Date Added: 09 Oct 2015 10:21
Last Modified: 19 Oct 2015 14:31
URI: http://irep.ntu.ac.uk/id/eprint/11713

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