YUN, T.J., TALLQUIST, M.D., AICHER, A., RAFFERTY, K.L., MARSHALL, A.J., MOON, J.J., EWINGS, M.K., MOHAUPT, M., HERRING, S.W. and CLARK, E.A., 2001. Osteoprotegerin, a crucial regulator of bone metabolism, also regulates B cell development and function. Journal of Immunology, 166 (3), pp. 1482-1491. ISSN 0022-1767Full text not available from this repository.
Osteoprotegerin (OPG) is a CD40-regulated gene in B cells and dendritic cells (DCs). We investigated the role of OPG in the immune system by generating opg-/- mice. Like its role as a regulator of bone metabolism, OPG also influences processes in the immune system, notably in B cell development. Ex vivo, opg-/- pro-B cells have enhanced proliferation to IL-7, and in opg-/- spleen, there is an accumulation of type 1 transitional B cells. Furthermore, opg-/- bone marrow-derived DCs are more effective in stimulating allogeneic T cells than control DCs. When challenged with a T-dependent Ag, opg-/- mice had a compromised ability to sustain an IgG3 Ag-specific response. Thus, in the immune system, OPG regulates B cell maturation and development of efficient Ab responses.
|Item Type:||Journal article|
|Publication Title:||Journal of Immunology|
|Creators:||Yun, T.J., Tallquist, M.D., Aicher, A., Rafferty, K.L., Marshall, A.J., Moon, J.J., Ewings, M.K., Mohaupt, M., Herring, S.W. and Clark, E.A.|
|Publisher:||American Association of Immunologists|
|Rights:||Copyright © 2001 by The American Association of Immunologists, Inc. All rights reserved.|
|Divisions:||Schools > School of Science and Technology|
|Depositing User:||EPrints Services|
|Date Added:||09 Oct 2015 10:21|
|Last Modified:||19 Oct 2015 14:31|
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