Yun, TJ, Tallquist, MD, Aicher, A, Rafferty, KL, Marshall, AJ, Moon, JJ, Ewings, MK, Mohaupt, M, Herring, SW and Clark, EA, 2001. Osteoprotegerin, a crucial regulator of bone metabolism, also regulates B cell development and function. Journal of Immunology, 166 (3), pp. 1482-1491. ISSN 0022-1767
Full text not available from this repository.Abstract
Osteoprotegerin (OPG) is a CD40-regulated gene in B cells and dendritic cells (DCs). We investigated the role of OPG in the immune system by generating opg-/- mice. Like its role as a regulator of bone metabolism, OPG also influences processes in the immune system, notably in B cell development. Ex vivo, opg-/- pro-B cells have enhanced proliferation to IL-7, and in opg-/- spleen, there is an accumulation of type 1 transitional B cells. Furthermore, opg-/- bone marrow-derived DCs are more effective in stimulating allogeneic T cells than control DCs. When challenged with a T-dependent Ag, opg-/- mice had a compromised ability to sustain an IgG3 Ag-specific response. Thus, in the immune system, OPG regulates B cell maturation and development of efficient Ab responses.
Item Type: | Journal article |
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Publication Title: | Journal of Immunology |
Creators: | Yun, T.J., Tallquist, M.D., Aicher, A., Rafferty, K.L., Marshall, A.J., Moon, J.J., Ewings, M.K., Mohaupt, M., Herring, S.W. and Clark, E.A. |
Publisher: | American Association of Immunologists |
Date: | 2001 |
Volume: | 166 |
Number: | 3 |
ISSN: | 0022-1767 |
Rights: | Copyright © 2001 by The American Association of Immunologists, Inc. All rights reserved. |
Divisions: | Schools > School of Science and Technology |
Record created by: | EPrints Services |
Date Added: | 09 Oct 2015 10:21 |
Last Modified: | 19 Oct 2015 14:31 |
URI: | https://irep.ntu.ac.uk/id/eprint/11713 |
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