Novel interactions of transglutaminase-2 with heparan sulphate proteoglycans: reflection on physiological implications

VERDERIO, E., SCARPELLINI, A. and JOHNSON, T., 2008. Novel interactions of transglutaminase-2 with heparan sulphate proteoglycans: reflection on physiological implications. Amino Acids, 36 (4), pp. 671-677.

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Abstract

This mini-review brings together information from publications and recent conference proceedings that have shed light on the biological interaction between transglutaminase-2 and heparan sulphate proteoglycans. We subsequently draw hypothesis of possible implications in the wound healing process. There is a substantial overlap in the action of transglutaminase-2 and the heparan sulphate proteoglycan syndecan-4 in normal and abnormal wound repair. Our latest findings have identified syndecan-4 as a possible binding and signalling partner of fibronectinbound TG2 and support the idea that transglutaminase-2 and syndecan-4 acts in synergy.

Item Type: Journal article
Description: The original publication is available at www.springerlink.com.
Publication Title: Amino Acids
Creators: Verderio, E., Scarpellini, A. and Johnson, T.
Publisher: Springer Verlag
Date: 2008
Volume: 36
Number: 4
Identifiers:
NumberType
10.1007/s00726-008-0134-6DOI
Rights: © 2008 Springer, part of Springer Science+Business Media
Divisions: Schools > School of Science and Technology
Depositing User: EPrints Services
Date Added: 09 Oct 2015 10:25
Last Modified: 23 Aug 2016 09:09
URI: http://irep.ntu.ac.uk/id/eprint/12778

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