Novel interactions of transglutaminase-2 with heparan sulphate proteoglycans: reflection on physiological implications

Verderio, E ORCID: https://orcid.org/0000-0001-9153-8997, Scarpellini, A and Johnson, T, 2008. Novel interactions of transglutaminase-2 with heparan sulphate proteoglycans: reflection on physiological implications. Amino Acids, 36 (4), pp. 671-677.

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Abstract

This mini-review brings together information from publications and recent conference proceedings that have shed light on the biological interaction between transglutaminase-2 and heparan sulphate proteoglycans. We subsequently draw hypothesis of possible implications in the wound healing process. There is a substantial overlap in the action of transglutaminase-2 and the heparan sulphate proteoglycan syndecan-4 in normal and abnormal wound repair. Our latest findings have identified syndecan-4 as a possible binding and signalling partner of fibronectinbound TG2 and support the idea that transglutaminase-2 and syndecan-4 acts in synergy.

Item Type:	Journal article
Description:	The original publication is available at www.springerlink.com.
Publication Title:	Amino Acids
Creators:	Verderio, E., Scarpellini, A. and Johnson, T.
Publisher:	Springer Verlag
Date:	2008
Volume:	36
Number:	4
Identifiers:	Number Type 10.1007/s00726-008-0134-6 DOI
Rights:	© 2008 Springer, part of Springer Science+Business Media
Divisions:	Schools > School of Science and Technology
Record created by:	EPrints Services
Date Added:	09 Oct 2015 10:25
Last Modified:	09 Jun 2017 13:29
URI:	https://irep.ntu.ac.uk/id/eprint/12778

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