Rings in the Extreme: PCNA Interactions and Adaptations in the Archaea

Winter, J.A. ORCID: 0000-0003-3582-7596 and Bunting, K.A., 2012. Rings in the Extreme: PCNA Interactions and Adaptations in the Archaea. Archaea, 2012, pp. 1-8. ISSN 1472-3646

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Abstract

Biochemical and structural analysis of archaeal proteins has enabled us to gain great insight into many eukaryotic processes, simultaneously offering fascinating glimpses into the adaptation and evolution of proteins at the extremes of life. The archaeal PCNAs, central to DNA replication and repair, are no exception. Characterisation of the proteins alone, and in complex with both peptides and protein binding partners, has demonstrated the diversity and subtlety in the regulatory role of these sliding clamps. Equally, studies have provided valuable detailed insight into the adaptation of protein interactions and mechanisms that are necessary for life in extreme environments.

Item Type: Journal article
Publication Title: Archaea
Creators: Winter, J.A. and Bunting, K.A.
Publisher: Hindawi Publishing Corporation
Date: 2012
Volume: 2012
ISSN: 1472-3646
Identifiers:
NumberType
10.1155/2012/951010DOI
Divisions: Schools > School of Science and Technology
Depositing User: Linda Sullivan
Date Added: 10 Nov 2015 09:40
Last Modified: 09 Jun 2017 13:56
URI: http://irep.ntu.ac.uk/id/eprint/26209

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