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Coutts, A.S. 
ORCID: 0000-0002-5005-1864 and La Thangue, N.B.,
2016.
Regulation of actin nucleation and autophagosome formation.
Cellular and Molecular Life Sciences, 73 (17), pp. 3249-3263.
ISSN 1420-682X
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Abstract
Autophagy is a process of self-eating, whereby cytosolic constituents are enclosed by a double-membrane vesicle before delivery to the lysosome for degradation. This is an important process which allows for recycling of nutrients and cellular components and thus plays a critical role in normal cellular homeostasis as well as cell survival during stresses such as starvation or hypoxia. A large number of proteins regulate various stages of autophagy in a complex and still incompletely understood series of events. In this review, we will discuss recent studies which provide a growing body of evidence that actin dynamics and proteins that influence actin nucleation play an important role in the regulation of autophagosome formation and maturation.
| Item Type: | Journal article | ||||||
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| Publication Title: | Cellular and Molecular Life Sciences | ||||||
| Creators: | Coutts, A.S. and La Thangue, N.B. | ||||||
| Publisher: | Springer | ||||||
| Date: | September 2016 | ||||||
| Volume: | 73 | ||||||
| Number: | 17 | ||||||
| ISSN: | 1420-682X | ||||||
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| Divisions: | Schools > School of Science and Technology | ||||||
| Record created by: | Linda Sullivan | ||||||
| Date Added: | 21 Sep 2016 10:59 | ||||||
| Last Modified: | 13 Oct 2017 15:38 | ||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/28593 |
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