Regulation of actin nucleation and autophagosome formation

Coutts, AS ORCID: https://orcid.org/0000-0002-5005-1864 and La Thangue, NB, 2016. Regulation of actin nucleation and autophagosome formation. Cellular and Molecular Life Sciences, 73 (17), pp. 3249-3263. ISSN 1420-682X

Preview

Text PubSub6198_Coutts.pdf - Published version Download (1MB) | Preview

Abstract

Autophagy is a process of self-eating, whereby cytosolic constituents are enclosed by a double-membrane vesicle before delivery to the lysosome for degradation. This is an important process which allows for recycling of nutrients and cellular components and thus plays a critical role in normal cellular homeostasis as well as cell survival during stresses such as starvation or hypoxia. A large number of proteins regulate various stages of autophagy in a complex and still incompletely understood series of events. In this review, we will discuss recent studies which provide a growing body of evidence that actin dynamics and proteins that influence actin nucleation play an important role in the regulation of autophagosome formation and maturation.

Item Type:	Journal article
Publication Title:	Cellular and Molecular Life Sciences
Creators:	Coutts, A.S. and La Thangue, N.B.
Publisher:	Springer
Date:	September 2016
Volume:	73
Number:	17
ISSN:	1420-682X
Identifiers:	Number Type 10.1007/s00018-016-2224-z DOI 2224 Publisher Item Identifier
Divisions:	Schools > School of Science and Technology
Record created by:	Linda Sullivan
Date Added:	21 Sep 2016 10:59
Last Modified:	13 Oct 2017 15:38
URI:	https://irep.ntu.ac.uk/id/eprint/28593

Actions (login required)

Edit View

Statistics

Views

Downloads