Regulation of actin nucleation and autophagosome formation

Coutts, A.S. ORCID: 0000-0002-5005-1864 and La Thangue, N.B., 2016. Regulation of actin nucleation and autophagosome formation. Cellular and Molecular Life Sciences, 73 (17), pp. 3249-3263. ISSN 1420-682X

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Abstract

Autophagy is a process of self-eating, whereby cytosolic constituents are enclosed by a double-membrane vesicle before delivery to the lysosome for degradation. This is an important process which allows for recycling of nutrients and cellular components and thus plays a critical role in normal cellular homeostasis as well as cell survival during stresses such as starvation or hypoxia. A large number of proteins regulate various stages of autophagy in a complex and still incompletely understood series of events. In this review, we will discuss recent studies which provide a growing body of evidence that actin dynamics and proteins that influence actin nucleation play an important role in the regulation of autophagosome formation and maturation.

Item Type: Journal article
Publication Title: Cellular and Molecular Life Sciences
Creators: Coutts, A.S. and La Thangue, N.B.
Publisher: Springer
Date: September 2016
Volume: 73
Number: 17
ISSN: 1420-682X
Identifiers:
NumberType
10.1007/s00018-016-2224-zDOI
2224Publisher Item Identifier
Divisions: Schools > School of Science and Technology
Depositing User: Linda Sullivan
Date Added: 21 Sep 2016 10:59
Last Modified: 13 Oct 2017 15:38
URI: http://irep.ntu.ac.uk/id/eprint/28593

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