Biodegradation-resistant multilayers coated with gold nanoparticles. Toward a tailor-made artificial extracellular matrix

Prokopović, V.Z., Vikulina, A.S., Sustr, D., Duschl, C. and Volodkin, D., 2016. Biodegradation-resistant multilayers coated with gold nanoparticles. Toward a tailor-made artificial extracellular matrix. ACS Applied Materials & Interfaces, 8 (37), pp. 24345-24349. ISSN 1944-8244

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Abstract

Polymer multicomponent coatings such as multilayers mimic extracellular matrix (ECM) that attracts significant attention for their use as functional supports for advanced cell culture and tissue engineering. Herein, biodegradation and molecular transport in hyaluronan/polylysine multilayers coated with gold nanoparticles was described. Nanoparticle coating acts as semipermeable barrier that governs molecular transport into/from the multilayers and makes them biodegradation resistant. Model protein lysozyme (mimics of ECM soluble signals) diffuses in the multilayers as fast and slow diffusing populations existing in an equilibrium. Such composite system may have high potential to be exploited as degradation-resistant drug delivery platforms suitable for cell-based applications. The extracellular matrix (ECM) provides not only a structural support for cell-based applications.

Item Type: Journal article
Publication Title: ACS Applied Materials & Interfaces
Creators: Prokopović, V.Z., Vikulina, A.S., Sustr, D., Duschl, C. and Volodkin, D.
Publisher: American Chemical Society
Date: 8 September 2016
Volume: 8
Number: 37
ISSN: 1944-8244
Identifiers:
NumberType
10.1021/acsami.6b10095DOI
Divisions: Schools > School of Science and Technology
Depositing User: Jonathan Gallacher
Date Added: 10 Oct 2017 12:50
Last Modified: 10 Oct 2017 12:50
URI: http://irep.ntu.ac.uk/id/eprint/31812

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