Prokopović, VZ, Vikulina, AS ORCID: https://orcid.org/0000-0001-9427-2055, Sustr, D, Duschl, C and Volodkin, D ORCID: https://orcid.org/0000-0001-7474-5329, 2016. Biodegradation-resistant multilayers coated with gold nanoparticles. Toward a tailor-made artificial extracellular matrix. ACS Applied Materials & Interfaces, 8 (37), pp. 24345-24349. ISSN 1944-8244
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Abstract
Polymer multicomponent coatings such as multilayers mimic extracellular matrix (ECM) that attracts significant attention for their use as functional supports for advanced cell culture and tissue engineering. Herein, biodegradation and molecular transport in hyaluronan/polylysine multilayers coated with gold nanoparticles was described. Nanoparticle coating acts as semipermeable barrier that governs molecular transport into/from the multilayers and makes them biodegradation resistant. Model protein lysozyme (mimics of ECM soluble signals) diffuses in the multilayers as fast and slow diffusing populations existing in an equilibrium. Such composite system may have high potential to be exploited as degradation-resistant drug delivery platforms suitable for cell-based applications. The extracellular matrix (ECM) provides not only a structural support for cell-based applications.
Item Type: | Journal article |
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Publication Title: | ACS Applied Materials & Interfaces |
Creators: | Prokopović, V.Z., Vikulina, A.S., Sustr, D., Duschl, C. and Volodkin, D. |
Publisher: | American Chemical Society |
Date: | 8 September 2016 |
Volume: | 8 |
Number: | 37 |
ISSN: | 1944-8244 |
Identifiers: | Number Type 10.1021/acsami.6b10095 DOI |
Divisions: | Schools > School of Science and Technology |
Record created by: | Jonathan Gallacher |
Date Added: | 10 Oct 2017 12:50 |
Last Modified: | 30 Jul 2019 14:42 |
URI: | https://irep.ntu.ac.uk/id/eprint/31812 |
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