Tools
Tools
Burton, C.G., Axford, D., Edwards, A.M.J. 
ORCID: 0000-0003-3338-1287, Gildea, R.J., Morris, R.H. ORCID: 0000-0001-5511-3457, Newton, M.I. ORCID: 0000-0003-4231-1002, Orville, A.M., Prince, M., Topham, P. and Docker, P.,
2017.
An acoustic on-chip goniometer for room temperature macromolecular crystallography.
Lab on a Chip, 17 (24), pp. 4225-4230.
ISSN 1473-0197
|
Text
PubSub9456_Newton.pdf - Post-print Download (1MB) | Preview |
Abstract
This paper describes the design, development and succesful use of an on-chip goniometer for room-temperature macromolecular crystallography via acoustically induced rotations. We present for the first time a low cost, rate-tunable, acoustic actuator for randomised in-fluid sample orientation and its utilisation for protein structure determination on a synchrotron beamline. The device enables the efficient collection of diffraction data via a rotation method from a sample within a surface confined droplet. This method facillitates efficient macromolecular structural data acquisition in fluid environments for dynamical studies.
| Item Type: | Journal article | ||||
|---|---|---|---|---|---|
| Publication Title: | Lab on a Chip | ||||
| Creators: | Burton, C.G., Axford, D., Edwards, A.M.J., Gildea, R.J., Morris, R.H., Newton, M.I., Orville, A.M., Prince, M., Topham, P. and Docker, P. | ||||
| Publisher: | Royal Society of Chemistry | ||||
| Date: | 1 November 2017 | ||||
| Volume: | 17 | ||||
| Number: | 24 | ||||
| ISSN: | 1473-0197 | ||||
| Identifiers: |
|
||||
| Divisions: | Schools > School of Science and Technology | ||||
| Record created by: | Linda Sullivan | ||||
| Date Added: | 08 Nov 2017 16:38 | ||||
| Last Modified: | 29 Oct 2020 16:48 | ||||
| URI: | https://irep.ntu.ac.uk/id/eprint/32001 |
Actions (login required)
 |
Edit View |
Views
Views per month over past year
Downloads
Downloads per month over past year
