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Adaikalakoteswari, A. 
ORCID: 0000-0003-2974-3388, Balasubramanyam, M., Ravikumar, R., Deepa, R. and Mohan, V.,
2007.
Association of telomere shortening with impaired glucose tolerance and diabetic macroangiopathy.
Atherosclerosis, 195 (1), pp. 83-89.
ISSN 0021-9150
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Abstract
Objective: Shortening of telomere length has been reported in several conditions including Type 2 diabetes and atherosclerosis. The aims of this study were (1) to assess whether telomere shortening occurs at the stage of pre-diabetes, i.e., impaired glucose tolerance (IGT) and (2) whether telomere shortening was greater in Type 2 diabetic subjects with atherosclerotic plaques.
Methods: Subjects with impaired glucose tolerance (IGT) (n = 30), non-diabetic control subjects (n = 30), Type 2 diabetic patients without (n = 30) and with atherosclerotic plaques (n = 30) were selected from the Chennai Urban Rural Epidemiology Study (CURES), an ongoing epidemiological population-based study. Southern-blot analysis was used to determine mean terminal restriction fragment (TRF) length, a measure of average telomere size, in leukocyte DNA. Levels of thiobarbituric acid reactive substances (TBARS), protein carbonyl content (PCO) and high sensitive C-reactive protein (hs-CRP) were measured by standard methodologies. Carotid intima-media thickness (IMT) was assessed by high resolution B-mode ultrasonography.
Results: The mean (±S.E.) TRF lengths were significantly lower in IGT subjects (6.97 ± 0.3 kb; p = 0.002) and lower still in Type 2 diabetic subjects without plaques (6.21 ± 0.2; p = 0.0001) and lowest in Type 2 diabetic subjects with atherosclerotic plaques (5.39 ± 0.2; p = 0.0001) when compared to control subjects (8.7 ± 0.5). In IGT subjects, TRF length was positively correlated to HDL cholesterol and negatively correlated to glycated hemoglobin (HbA1c), TBARS, PCO, HOMA-IR and IMT. In multiple linear regression analysis, presence of diabetes, HDL cholesterol and increased TBARS levels appear as significant determinants of telomere shortening.
Conclusion: Telomere shortening is seen even at the stage of IGT. Among subjects with Type 2 diabetes, those with atherosclerotic plaques had greater shortening of telomere length compared to those without plaques.
| Item Type: | Journal article | ||||||
|---|---|---|---|---|---|---|---|
| Publication Title: | Atherosclerosis | ||||||
| Creators: | Adaikalakoteswari, A., Balasubramanyam, M., Ravikumar, R., Deepa, R. and Mohan, V. | ||||||
| Publisher: | Elsevier Ireland Ltd. | ||||||
| Date: | November 2007 | ||||||
| Volume: | 195 | ||||||
| Number: | 1 | ||||||
| ISSN: | 0021-9150 | ||||||
| Identifiers: |
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| Rights: | Copyright © 2006 Elsevier Ireland Ltd. All rights reserved. | ||||||
| Divisions: | Schools > School of Science and Technology | ||||||
| Record created by: | Linda Sullivan | ||||||
| Date Added: | 04 May 2018 14:16 | ||||||
| Last Modified: | 04 May 2018 14:16 | ||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/33446 |
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