Dissecting the immune landscape of acute myeloid leukemia

Davidson-Moncada, J., Viboch, E., Church, S., Warren, S. and Rutella, S. ORCID: 0000-0003-1970-7375, 2018. Dissecting the immune landscape of acute myeloid leukemia. Biomedicines, 6 (4): 110. ISSN 2227-9059

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Abstract

Acute myeloid leukemia (AML) is a molecularly heterogeneous hematological malignancy with variable response to treatment. Recurring cytogenetic abnormalities and molecular lesions identify AML patient subgroups with different survival probabilities; however, 50–70% of AML cases harbor either normal or risk-indeterminate karyotypes. The discovery of better biomarkers of clinical success and failure is therefore necessary to inform tailored therapeutic decisions. Harnessing the immune system against cancer with programmed death-1 (PD-1)-directed immune checkpoint blockade (ICB) and other immunotherapy agents is an effective therapeutic option for several advanced malignancies. However, durable responses have been observed in only a minority of patients, highlighting the need to gain insights into the molecular features that predict response and to also develop more effective and rational combination therapies that address mechanisms of immune evasion and resistance. We will review the state of knowledge of the immune landscape of AML and identify the broad opportunity to further explore this incompletely characterized space. Multiplexed, spatially-resolved immunohistochemistry, flow cytometry/mass cytometry, proteomic and transcriptomic approaches are advancing our understanding of the complexity of AML-immune interactions and are expected to support the design and expedite the delivery of personalized immunotherapy clinical trials.

Item Type: Journal article
Description: This article belongs to the special issue: Dissecting the immunological landscape of human malignancies
Publication Title: Biomedicines
Creators: Davidson-Moncada, J., Viboch, E., Church, S., Warren, S. and Rutella, S.
Publisher: MDPI
Date: 25 November 2018
Volume: 6
Number: 4
ISSN: 2227-9059
Identifiers:
NumberType
10.3390/biomedicines6040110DOI
biomedicines6040110Publisher Item Identifier
Divisions: Schools > School of Science and Technology
Depositing User: Jonathan Gallacher
Date Added: 18 Dec 2018 09:29
Last Modified: 18 Dec 2018 09:29
URI: http://irep.ntu.ac.uk/id/eprint/35363

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