Davidson-Moncada, J, Viboch, E, Church, S, Warren, S and Rutella, S ORCID: https://orcid.org/0000-0003-1970-7375, 2018. Dissecting the immune landscape of acute myeloid leukemia. Biomedicines, 6 (4): 110. ISSN 2227-9059
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Abstract
Acute myeloid leukemia (AML) is a molecularly heterogeneous hematological malignancy with variable response to treatment. Recurring cytogenetic abnormalities and molecular lesions identify AML patient subgroups with different survival probabilities; however, 50–70% of AML cases harbor either normal or risk-indeterminate karyotypes. The discovery of better biomarkers of clinical success and failure is therefore necessary to inform tailored therapeutic decisions. Harnessing the immune system against cancer with programmed death-1 (PD-1)-directed immune checkpoint blockade (ICB) and other immunotherapy agents is an effective therapeutic option for several advanced malignancies. However, durable responses have been observed in only a minority of patients, highlighting the need to gain insights into the molecular features that predict response and to also develop more effective and rational combination therapies that address mechanisms of immune evasion and resistance. We will review the state of knowledge of the immune landscape of AML and identify the broad opportunity to further explore this incompletely characterized space. Multiplexed, spatially-resolved immunohistochemistry, flow cytometry/mass cytometry, proteomic and transcriptomic approaches are advancing our understanding of the complexity of AML-immune interactions and are expected to support the design and expedite the delivery of personalized immunotherapy clinical trials.
Item Type: | Journal article |
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Description: | This article belongs to the special issue: Dissecting the immunological landscape of human malignancies |
Publication Title: | Biomedicines |
Creators: | Davidson-Moncada, J., Viboch, E., Church, S., Warren, S. and Rutella, S. |
Publisher: | MDPI |
Date: | 25 November 2018 |
Volume: | 6 |
Number: | 4 |
ISSN: | 2227-9059 |
Identifiers: | Number Type 10.3390/biomedicines6040110 DOI biomedicines6040110 Publisher Item Identifier |
Divisions: | Schools > School of Science and Technology |
Record created by: | Jonathan Gallacher |
Date Added: | 18 Dec 2018 09:29 |
Last Modified: | 18 Dec 2018 09:29 |
URI: | https://irep.ntu.ac.uk/id/eprint/35363 |
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