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Jeannot, L., Bell, M., Ashwell, R., Volodkin, D. 
ORCID: 0000-0001-7474-5329 and Vikulina, A.S. ORCID: 0000-0001-9427-2055,
2018.
Internal structure of matrix-type multilayer capsules templated on porous vaterite CaCO3 crystals as probed by staining with a fluorescence dye.
Micromachines, 9 (11): 547.
ISSN 2072-666X
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Abstract
Multilayer capsules templated on decomposable vaterite CaCO3 crystals are widely used as vehicles for drug delivery. The capsule represents typically not a hollow but matrix-like structure due to polymer diffusion into the porous crystals during multilayer deposition. The capsule formation mechanism is not well-studied but its understanding is crucial to tune capsule structure for a proper drug release performance. This study proposes new approach to noninvasively probe and adjust internal capsule structure. Polymer capsules made of poly(styrene-sulfonate) (PSS) and poly(diallyldimethylammonium chloride) (PDAD) have been stained with fluorescence dye rhodamine 6G. Physical-chemical aspects of intermolecular interactions required to validate the approach and adjust capsule structure are addressed. The capsules consist of a defined shell (typically 0.5–2 µm) and an internal matrix of PSS-PDAD complex (typically 10–40% of a total capsule volume). An increase of ionic strength and polymer deposition time leads to the thickening of the capsule shell and formation of a denser internal matrix, respectively. This is explained by effects of a polymer conformation and limitations in polymer diffusion through the crystal pores. We believe that the design of the capsules with desired internal structure will allow achieving effective encapsulation and controlled/programmed release of bioactives for advanced drug delivery applications.
| Item Type: | Journal article | ||||||
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| Publication Title: | Micromachines | ||||||
| Creators: | Jeannot, L., Bell, M., Ashwell, R., Volodkin, D. and Vikulina, A.S. | ||||||
| Publisher: | MDPI | ||||||
| Date: | 25 October 2018 | ||||||
| Volume: | 9 | ||||||
| Number: | 11 | ||||||
| ISSN: | 2072-666X | ||||||
| Identifiers: |
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| Rights: | © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | ||||||
| Divisions: | Schools > School of Science and Technology | ||||||
| Record created by: | Jonathan Gallacher | ||||||
| Date Added: | 03 May 2019 09:02 | ||||||
| Last Modified: | 30 Jul 2019 14:30 | ||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/36405 |
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