Internal structure of matrix-type multilayer capsules templated on porous vaterite CaCO3 crystals as probed by staining with a fluorescence dye

Jeannot, L, Bell, M, Ashwell, R, Volodkin, D ORCID: https://orcid.org/0000-0001-7474-5329 and Vikulina, AS ORCID: https://orcid.org/0000-0001-9427-2055, 2018. Internal structure of matrix-type multilayer capsules templated on porous vaterite CaCO3 crystals as probed by staining with a fluorescence dye. Micromachines, 9 (11): 547. ISSN 2072-666X

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Abstract

Multilayer capsules templated on decomposable vaterite CaCO3 crystals are widely used as vehicles for drug delivery. The capsule represents typically not a hollow but matrix-like structure due to polymer diffusion into the porous crystals during multilayer deposition. The capsule formation mechanism is not well-studied but its understanding is crucial to tune capsule structure for a proper drug release performance. This study proposes new approach to noninvasively probe and adjust internal capsule structure. Polymer capsules made of poly(styrene-sulfonate) (PSS) and poly(diallyldimethylammonium chloride) (PDAD) have been stained with fluorescence dye rhodamine 6G. Physical-chemical aspects of intermolecular interactions required to validate the approach and adjust capsule structure are addressed. The capsules consist of a defined shell (typically 0.5–2 µm) and an internal matrix of PSS-PDAD complex (typically 10–40% of a total capsule volume). An increase of ionic strength and polymer deposition time leads to the thickening of the capsule shell and formation of a denser internal matrix, respectively. This is explained by effects of a polymer conformation and limitations in polymer diffusion through the crystal pores. We believe that the design of the capsules with desired internal structure will allow achieving effective encapsulation and controlled/programmed release of bioactives for advanced drug delivery applications.

Item Type:	Journal article
Publication Title:	Micromachines
Creators:	Jeannot, L., Bell, M., Ashwell, R., Volodkin, D. and Vikulina, A.S.
Publisher:	MDPI
Date:	25 October 2018
Volume:	9
Number:	11
ISSN:	2072-666X
Identifiers:	Number Type 10.3390/mi9110547 DOI mi9110547 Publisher Item Identifier
Rights:	© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Divisions:	Schools > School of Science and Technology
Record created by:	Jonathan Gallacher
Date Added:	03 May 2019 09:02
Last Modified:	30 Jul 2019 14:30
URI:	https://irep.ntu.ac.uk/id/eprint/36405

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