Genotyping of the Alzheimer's disease genome-wide association study index single nucleotide polymorphisms in the brains for dementia research cohort

Tools

Brookes, K.J. ORCID: 0000-0003-2427-2513, McConnell, G., Williams, K., Chaudhury, S., Madhan, G., Patel, T., Turley, C., Guetta-Baranes, T., Bras, J., Guerreiro, R., Hardy, J., Francis, P.T. and Morgan, K., 2018. Genotyping of the Alzheimer's disease genome-wide association study index single nucleotide polymorphisms in the brains for dementia research cohort. Journal of Alzheimer's Disease, 64 (2), pp. 355-362. ISSN 1387-2877

Preview

Text
13920_Brookes.pdf - Post-print
Download (509kB) | Preview

Official URL: http://doi.org/10.3233/jad-180191

Abstract

The Brains for Dementia Research project is a recently established longitudinal cohort which aims to provide brain tissue for research purposes from neuropathologically defined samples. Here we present the findings from our analysis on the 19 established GWAS index SNPs for Alzheimer’s disease, in order to demonstrate if the BDR sample also displays association to these variants. A highly significant association of the APOE ɛ4 allele was identified (p = 3.99×10–12). Association tests for the 19 GWAS SNPs found that although no SNPs survive multiple testing, nominal significant findings were detected and concordance with the Lambert et al. GWAS meta-analysis was observed.

Item Type:

Journal article

Alternative Title:

Genotyping GWAS variants in BDR [running title]

Publication Title:

Journal of Alzheimer's Disease

Creators:

Brookes, K.J., McConnell, G., Williams, K., Chaudhury, S., Madhan, G., Patel, T., Turley, C., Guetta-Baranes, T., Bras, J., Guerreiro, R., Hardy, J., Francis, P.T. and Morgan, K.

Publisher:

IOS Press

Date:

2018

Volume:

Number:

ISSN:

1387-2877

Identifiers: