Genotyping of the Alzheimer's disease genome-wide association study index single nucleotide polymorphisms in the brains for dementia research cohort

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Brookes, KJ ORCID: https://orcid.org/0000-0003-2427-2513, McConnell, G, Williams, K, Chaudhury, S, Madhan, G, Patel, T, Turley, C, Guetta-Baranes, T, Bras, J, Guerreiro, R, Hardy, J, Francis, PT and Morgan, K, 2018. Genotyping of the Alzheimer's disease genome-wide association study index single nucleotide polymorphisms in the brains for dementia research cohort. Journal of Alzheimer's Disease, 64 (2), pp. 355-362. ISSN 1387-2877

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Official URL: http://doi.org/10.3233/jad-180191

Abstract

The Brains for Dementia Research project is a recently established longitudinal cohort which aims to provide brain tissue for research purposes from neuropathologically defined samples. Here we present the findings from our analysis on the 19 established GWAS index SNPs for Alzheimer’s disease, in order to demonstrate if the BDR sample also displays association to these variants. A highly significant association of the APOE ɛ4 allele was identified (p = 3.99×10–12). Association tests for the 19 GWAS SNPs found that although no SNPs survive multiple testing, nominal significant findings were detected and concordance with the Lambert et al. GWAS meta-analysis was observed.

Item Type:	Journal article
Alternative Title:	Genotyping GWAS variants in BDR [running title]
Publication Title:	Journal of Alzheimer's Disease
Creators:	Brookes, K.J., McConnell, G., Williams, K., Chaudhury, S., Madhan, G., Patel, T., Turley, C., Guetta-Baranes, T., Bras, J., Guerreiro, R., Hardy, J., Francis, P.T. and Morgan, K.
Publisher:	IOS Press
Date:	2018
Volume:	64
Number:	2
ISSN:	1387-2877
Identifiers:	Number Type 10.3233/jad-180191 DOI
Divisions:	Schools > School of Science and Technology
Record created by:	Linda Sullivan
Date Added:	13 May 2019 09:10
Last Modified:	13 May 2019 09:10
URI:	https://irep.ntu.ac.uk/id/eprint/36458