A novel and highly stereoselective route for the synthesis of non-racemic 3-substituted isoindolin-1-one targets

Hemming, R.A., Bell, M., Duffy, L.J., Bristow, J., Wallis, J.D. ORCID: 0000-0001-7259-8783, Allin, S.M. ORCID: 0000-0001-5198-9339 and Bulman Page, P.C., 2019. A novel and highly stereoselective route for the synthesis of non-racemic 3-substituted isoindolin-1-one targets. Tetrahedron, 75 (1), pp. 121-127. ISSN 0040-4020

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Abstract

A new, versatile and highly stereoselective approach for the synthesis of non-racemic 3-substituted isoindolin-1-ones is described from a readily available chiral template. The potential of this new protocol is demonstrated through the synthesis of an enantiomerically enriched 3-alkyl N-H isoindolin-1-one target with an e.e. of 98%.

Item Type: Journal article
Publication Title: Tetrahedron
Creators: Hemming, R.A., Bell, M., Duffy, L.J., Bristow, J., Wallis, J.D., Allin, S.M. and Bulman Page, P.C.
Publisher: Elsevier
Date: 3 January 2019
Volume: 75
Number: 1
ISSN: 0040-4020
Identifiers:
NumberType
10.1016/j.tet.2018.11.050DOI
S0040402018314054Publisher Item Identifier
Divisions: Schools > School of Science and Technology
Depositing User: Linda Sullivan
Date Added: 18 Jul 2019 15:17
Last Modified: 16 Aug 2019 13:56
URI: http://irep.ntu.ac.uk/id/eprint/37120

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