A novel and highly stereoselective route for the synthesis of non-racemic 3-substituted isoindolin-1-one targets

Hemming, RA, Bell, M, Duffy, LJ, Bristow, J, Wallis, JD ORCID: https://orcid.org/0000-0001-7259-8783, Allin, SM ORCID: https://orcid.org/0000-0001-5198-9339 and Bulman Page, PC, 2019. A novel and highly stereoselective route for the synthesis of non-racemic 3-substituted isoindolin-1-one targets. Tetrahedron, 75 (1), pp. 121-127. ISSN 0040-4020

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Abstract

A new, versatile and highly stereoselective approach for the synthesis of non-racemic 3-substituted isoindolin-1-ones is described from a readily available chiral template. The potential of this new protocol is demonstrated through the synthesis of an enantiomerically enriched 3-alkyl N-H isoindolin-1-one target with an e.e. of 98%.

Item Type:	Journal article
Publication Title:	Tetrahedron
Creators:	Hemming, R.A., Bell, M., Duffy, L.J., Bristow, J., Wallis, J.D., Allin, S.M. and Bulman Page, P.C.
Publisher:	Elsevier
Date:	3 January 2019
Volume:	75
Number:	1
ISSN:	0040-4020
Identifiers:	Number Type 10.1016/j.tet.2018.11.050 DOI S0040402018314054 Publisher Item Identifier
Divisions:	Schools > School of Science and Technology
Record created by:	Linda Sullivan
Date Added:	18 Jul 2019 15:17
Last Modified:	31 May 2021 15:13
URI:	https://irep.ntu.ac.uk/id/eprint/37120

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