Effects of dietary nitrate supplementation on microvascular physiology at 4559 m altitude – a randomised controlled trial (Xtreme Alps)

Cumpstey, A.F., Hennis, P.J. ORCID: 0000-0002-8216-998X, Gilbert-Kawai, E.T., Fernandez, B.O., Grant, D., Jenner, W., Poudevigne, M., Moyses, H., Levett, D.Z., Cobb, A., Meale, P., Mitchell, K., Pöhnl, H., Mythen, M.G., Grocott, M.P., Martin, D.S. and Feelisch, M., 2020. Effects of dietary nitrate supplementation on microvascular physiology at 4559 m altitude – a randomised controlled trial (Xtreme Alps). Nitric Oxide, 94, pp. 27-35. ISSN 1089-8603

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Abstract

Native highlanders (e.g. Sherpa) demonstrate remarkable hypoxic tolerance, possibly secondary to higher levels of circulating nitric oxide (NO) and increased microcirculatory blood flow. As part of the Xtreme Alps study (a randomised placebo-controlled trial of dietary nitrate supplementation under field conditions of hypobaric hypoxia), we investigated whether dietary supplementation with nitrate could improve NO availability and microvascular blood flow in lowlanders. Plasma measurements of nitrate, nitrite and nitroso species were performed together with measurements of sublingual (sidestream dark-field camera) and forearm blood flow (venous occlusion plethysmography) in 28 healthy adult volunteers resident at 4559 m for 1 week; half receiving a beetroot-based high-nitrate supplement and half receiving an identically-tasting low nitrate 'placebo'. Dietary supplementation increased plasma nitrate concentrations 4-fold compared to the placebo group, both at sea level (SL; 19.2 vs 76.9 μM) and at day 5 (D5) of high altitude (22.9 vs 84.3 μM, p

Item Type: Journal article
Publication Title: Nitric Oxide
Creators: Cumpstey, A.F., Hennis, P.J., Gilbert-Kawai, E.T., Fernandez, B.O., Grant, D., Jenner, W., Poudevigne, M., Moyses, H., Levett, D.Z., Cobb, A., Meale, P., Mitchell, K., Pöhnl, H., Mythen, M.G., Grocott, M.P., Martin, D.S. and Feelisch, M.
Publisher: Elsevier
Date: January 2020
Volume: 94
ISSN: 1089-8603
Identifiers:
NumberType
10.1016/j.niox.2019.10.004DOI
1201971Other
S1089860319302071Publisher Item Identifier
Rights: © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).
Divisions: Schools > School of Science and Technology
Record created by: Linda Sullivan
Date Added: 22 Oct 2019 08:00
Last Modified: 22 Oct 2019 08:00
URI: http://irep.ntu.ac.uk/id/eprint/38012

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