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Cumpstey, AF, Hennis, PJ 
ORCID: https://orcid.org/0000-0002-8216-998X, Gilbert-Kawai, ET, Fernandez, BO, Grant, D, Jenner, W, Poudevigne, M, Moyses, H, Levett, DZ, Cobb, A, Meale, P, Mitchell, K, Pöhnl, H, Mythen, MG, Grocott, MP, Martin, DS and Feelisch, M,
2020.
Effects of dietary nitrate supplementation on microvascular physiology at 4559 m altitude – a randomised controlled trial (Xtreme Alps).
Nitric Oxide, 94, pp. 27-35.
ISSN 1089-8603
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Abstract
Native highlanders (e.g. Sherpa) demonstrate remarkable hypoxic tolerance, possibly secondary to higher levels of circulating nitric oxide (NO) and increased microcirculatory blood flow. As part of the Xtreme Alps study (a randomised placebo-controlled trial of dietary nitrate supplementation under field conditions of hypobaric hypoxia), we investigated whether dietary supplementation with nitrate could improve NO availability and microvascular blood flow in lowlanders. Plasma measurements of nitrate, nitrite and nitroso species were performed together with measurements of sublingual (sidestream dark-field camera) and forearm blood flow (venous occlusion plethysmography) in 28 healthy adult volunteers resident at 4559 m for 1 week; half receiving a beetroot-based high-nitrate supplement and half receiving an identically-tasting low nitrate 'placebo'. Dietary supplementation increased plasma nitrate concentrations 4-fold compared to the placebo group, both at sea level (SL; 19.2 vs 76.9 μM) and at day 5 (D5) of high altitude (22.9 vs 84.3 μM, p
| Item Type: | Journal article |
|---|---|
| Publication Title: | Nitric Oxide |
| Creators: | Cumpstey, A.F., Hennis, P.J., Gilbert-Kawai, E.T., Fernandez, B.O., Grant, D., Jenner, W., Poudevigne, M., Moyses, H., Levett, D.Z., Cobb, A., Meale, P., Mitchell, K., Pöhnl, H., Mythen, M.G., Grocott, M.P., Martin, D.S. and Feelisch, M. |
| Publisher: | Elsevier |
| Date: | January 2020 |
| Volume: | 94 |
| ISSN: | 1089-8603 |
| Identifiers: | Number Type 10.1016/j.niox.2019.10.004 DOI 1201971 Other S1089860319302071 Publisher Item Identifier |
| Rights: | © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/). |
| Divisions: | Schools > School of Science and Technology |
| Record created by: | Linda Sullivan |
| Date Added: | 22 Oct 2019 08:00 |
| Last Modified: | 22 Oct 2019 08:00 |
| URI: | https://irep.ntu.ac.uk/id/eprint/38012 |
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