Evolution of generalist resistance to herbicide mixtures reveals a trade-off in resistance management

Comont, D., Lowe, C., Hull, R., Crook, L., Hicks, H. ORCID: 0000-0003-1325-2293, Onkokesung, N., Beffa, R., Childs, D.Z., Edwards, R., Freckleton, R.P. and Neve, P., 2020. Evolution of generalist resistance to herbicide mixtures reveals a trade-off in resistance management. Nature Communications. ISSN 2041-1723 (Forthcoming)

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Abstract

Intense selection by pesticides and antibiotics has resulted in a global epidemic of evolved resistance. In agriculture and medicine, using mixtures of compounds from different classes is widely accepted as optimal resistance management. However, this strategy may promote the evolution of more generalist resistance mechanisms. Here we test this hypothesis at a national-scale in an economically important agricultural weed: blackgrass (Alopecurus myosuroides), for which herbicide resistance is a major economic issue. Our results reveal that greater use of herbicide mixtures is associated with lower levels of specialist resistance mechanisms, but higher levels of a generalist mechanism implicated in enhanced metabolism of herbicides with diverse modes of action. Our results indicate a potential evolutionary trade-off in resistance management, whereby attempts to reduce selection for specialist resistance traits may promote the evolution of generalist resistance. We contend that where specialist and generalist resistance mechanisms co-occur, similar trade-offs will be evident, calling into question the ubiquity of resistance management based on mixtures and combination therapies.

Item Type: Journal article
Publication Title: Nature Communications
Creators: Comont, D., Lowe, C., Hull, R., Crook, L., Hicks, H., Onkokesung, N., Beffa, R., Childs, D.Z., Edwards, R., Freckleton, R.P. and Neve, P.
Publisher: Nature Research (part of Springer Nature)
Date: 26 May 2020
ISSN: 2041-1723
Identifiers:
NumberType
1332423Other
Divisions: Schools > School of Animal, Rural and Environmental Sciences
Record created by: Jill Tomkinson
Date Added: 16 Jun 2020 13:14
Last Modified: 07 Jul 2020 07:44
URI: http://irep.ntu.ac.uk/id/eprint/40004

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