Identifying prostate cancer and its clinical risk in asymptomatic men using machine learning of high dimensional peripheral blood flow cytometric natural killer cell subset phenotyping data

Hood, S.P., Cosma, G. ORCID: 0000-0002-4663-6907, Foulds, G.A. ORCID: 0000-0002-2053-7580, Johnson, C., Reeder, S., McArdle, S.E. ORCID: 0000-0001-6929-9782, Khan, M.A. and Pockley, A.G. ORCID: 0000-0001-9593-6431, 2020. Identifying prostate cancer and its clinical risk in asymptomatic men using machine learning of high dimensional peripheral blood flow cytometric natural killer cell subset phenotyping data. eLife, 9: e50936.

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Abstract

We demonstrate that prostate cancer can be identified by flow cytometric profiling of blood immune cell subsets. Herein, we profiled natural killer (NK) cell subsets in the blood of 72 asymptomatic men with Prostate-Specific Antigen (PSA) levels < 20 ng ml-1, of whom 31 had benign disease (no cancer) and 41 had prostate cancer. Statistical and computational methods identified a panel of eight phenotypic features (CD56dimCD16high, CD56+DNAM−1−, CD56+LAIR−1+, CD56+LAIR−1−, CD56brightCD8+, CD56+NKp30+, CD56+NKp30−, CD56+NKp46+) that, when incorporated into an Ensemble machine learning prediction model, distinguished between the presence of benign prostate disease and prostate cancer. The machine learning model was then adapted to predict the D’Amico Risk Classification using data from 54 patients with prostate cancer and was shown to accurately differentiate between the presence of low-/intermediate-risk disease and high-risk disease without the need for additional clinical data. This simple blood test has the potential to transform prostate cancer diagnostics.

Item Type: Journal article
Publication Title: eLife
Creators: Hood, S.P., Cosma, G., Foulds, G.A., Johnson, C., Reeder, S., McArdle, S.E., Khan, M.A. and Pockley, A.G.
Publisher: eLife Sciences Publications, Ltd
Date: 28 July 2020
Volume: 9
Identifiers:
NumberType
10.7554/elife.50936DOI
1349937Other
Rights: © Copyright Hood et al. eLife Sciences Publications Ltd. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Divisions: Schools > School of Science and Technology
Record created by: Linda Sullivan
Date Added: 04 Aug 2020 13:31
Last Modified: 04 Aug 2020 13:31
URI: http://irep.ntu.ac.uk/id/eprint/40312

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