Expanding the family of tetrahalide iron complexes: synthesis, structure and biological applications

Abedin, N., Hamed A Alshehri, A., Almughrbi, A.M.A., Moore, O., Alyza, S., Rusbridge, E.K., Masood, N., Egbowon, B.F., Hargreaves, A.J. ORCID: 0000-0001-9754-5477, Dafhnis-Calas, F. and Fitzpatrick, A.J. ORCID: 0000-0001-9436-8129, 2020. Expanding the family of tetrahalide iron complexes: synthesis, structure and biological applications. Polyhedron: 114755. ISSN 0277-5387

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Abstract

A neutral octahedral mononuclear iron(II) tetrabromide complex, [Fe(HaAmpy)2Br4], that consists of equatorial bromide and protonated aminopyrazinium axial ligands is successfully synthesised through redox chemistry and analysed using X-ray crystallography. The iron(II) oxidation state is balanced by the protonated pyrazinium nitrogen just outside the coordination sphere. The biological properties of this and two other related complexes are investigated using both Gram-negative and Gram-positive bacteria as well as methicillin resistant strains. They all exhibit some antimicrobial properties albeit at moderate to poor concentrations. However, the tetrahalide complexes analysed exhibit excellent anti-biofilm properties well below cytotoxic levels.

Item Type: Journal article
Publication Title: Polyhedron
Creators: Abedin, N., Hamed A Alshehri, A., Almughrbi, A.M.A., Moore, O., Alyza, S., Rusbridge, E.K., Masood, N., Egbowon, B.F., Hargreaves, A.J., Dafhnis-Calas, F. and Fitzpatrick, A.J.
Publisher: Elsevier
Date: 17 August 2020
ISSN: 0277-5387
Identifiers:
NumberType
10.1016/j.poly.2020.114755DOI
S0277538720304125Publisher Item Identifier
1353779Other
Divisions: Schools > School of Science and Technology
Record created by: Linda Sullivan
Date Added: 20 Aug 2020 07:51
Last Modified: 20 Aug 2020 07:51
URI: http://irep.ntu.ac.uk/id/eprint/40481

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