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Thackray, A.E., Willis, S.A., Clayton, D.J. 
ORCID: 0000-0001-5481-0891, Broom, D.R., Finlayson, G., Goltz, F.R., Sargeant, J.A., Woods, R.M., Stensel, D.J. and King, J.A.,
2020.
Influence of short-term hyperenergetic, high-fat feeding on appetite, appetite-related hormones, and food reward in healthy men.
Nutrients, 12 (9): 2635.
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Abstract
Short-term overfeeding may provoke compensatory appetite responses to correct the energy surplus. However, the initial time-course of appetite, appetite-related hormone, and reward-related responses to hyperenergetic, high-fat diets (HE-HFD) are poorly characterised. Twelve young healthy men consumed a HE-HFD (+50% energy, 65% fat) or control diet (36% fat) for seven days in a randomised crossover design. Mean appetite perceptions were determined during an oral glucose tolerance test (OGTT) before and after each diet. Fasted appetite perceptions, appetite-related hormones, and reward parameters were measured pre-diet and after 1-, 3- and 7-days of each diet. The HE-HFD induced a pre-to-post diet suppression in mean appetite during the OGTT (all ratings p ≤ 0.058, effect size (d) ≥ 0.31), and reduced the preference for high-fat vs. low-fat foods (main effect diet p = 0.036, d = 0.32). Fasted leptin was higher in the HE-HFD than control diet (main effect diet p < 0.001, d = 0.30), whilst a diet-by-time interaction (p = 0.036) revealed fasted acylated ghrelin was reduced after 1-, 3- and 7-days of the HE-HFD (all p ≤ 0.040, d ≥ 0.50 vs. pre-diet). Appetite perceptions and total peptide YY in the fasted state exhibited similar temporal patterns between the diets (diet-by-time interaction p ≥ 0.077). Seven days of high-fat overfeeding provokes modest compensatory changes in subjective, hormonal, and reward-related appetite parameters.
| Item Type: | Journal article | ||||||
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| Publication Title: | Nutrients | ||||||
| Creators: | Thackray, A.E., Willis, S.A., Clayton, D.J., Broom, D.R., Finlayson, G., Goltz, F.R., Sargeant, J.A., Woods, R.M., Stensel, D.J. and King, J.A. | ||||||
| Publisher: | MDPI AG | ||||||
| Date: | 2020 | ||||||
| Volume: | 12 | ||||||
| Number: | 9 | ||||||
| Identifiers: |
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| Rights: | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license http://creativecommons.org/licenses/by/4.0/). | ||||||
| Divisions: | Schools > School of Science and Technology | ||||||
| Record created by: | Linda Sullivan | ||||||
| Date Added: | 09 Sep 2020 08:52 | ||||||
| Last Modified: | 31 May 2021 15:17 | ||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/40643 |
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