Influence of short-term hyperenergetic, high-fat feeding on appetite, appetite-related hormones, and food reward in healthy men

Thackray, AE, Willis, SA, Clayton, DJ ORCID: https://orcid.org/0000-0001-5481-0891, Broom, DR, Finlayson, G, Goltz, FR, Sargeant, JA, Woods, RM, Stensel, DJ and King, JA, 2020. Influence of short-term hyperenergetic, high-fat feeding on appetite, appetite-related hormones, and food reward in healthy men. Nutrients, 12 (9): 2635.

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Abstract

Short-term overfeeding may provoke compensatory appetite responses to correct the energy surplus. However, the initial time-course of appetite, appetite-related hormone, and reward-related responses to hyperenergetic, high-fat diets (HE-HFD) are poorly characterised. Twelve young healthy men consumed a HE-HFD (+50% energy, 65% fat) or control diet (36% fat) for seven days in a randomised crossover design. Mean appetite perceptions were determined during an oral glucose tolerance test (OGTT) before and after each diet. Fasted appetite perceptions, appetite-related hormones, and reward parameters were measured pre-diet and after 1-, 3- and 7-days of each diet. The HE-HFD induced a pre-to-post diet suppression in mean appetite during the OGTT (all ratings p ≤ 0.058, effect size (d) ≥ 0.31), and reduced the preference for high-fat vs. low-fat foods (main effect diet p = 0.036, d = 0.32). Fasted leptin was higher in the HE-HFD than control diet (main effect diet p < 0.001, d = 0.30), whilst a diet-by-time interaction (p = 0.036) revealed fasted acylated ghrelin was reduced after 1-, 3- and 7-days of the HE-HFD (all p ≤ 0.040, d ≥ 0.50 vs. pre-diet). Appetite perceptions and total peptide YY in the fasted state exhibited similar temporal patterns between the diets (diet-by-time interaction p ≥ 0.077). Seven days of high-fat overfeeding provokes modest compensatory changes in subjective, hormonal, and reward-related appetite parameters.

Item Type:	Journal article
Publication Title:	Nutrients
Creators:	Thackray, A.E., Willis, S.A., Clayton, D.J., Broom, D.R., Finlayson, G., Goltz, F.R., Sargeant, J.A., Woods, R.M., Stensel, D.J. and King, J.A.
Publisher:	MDPI AG
Date:	2020
Volume:	12
Number:	9
Identifiers:	Number Type 10.3390/nu12092635 DOI 1362478 Other
Rights:	© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license http://creativecommons.org/licenses/by/4.0/).
Divisions:	Schools > School of Science and Technology
Record created by:	Linda Sullivan
Date Added:	09 Sep 2020 08:52
Last Modified:	31 May 2021 15:17
URI:	https://irep.ntu.ac.uk/id/eprint/40643

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