Tools
Tools
Dumbell, R. 
ORCID: 0000-0002-8805-3777, Matveeva, O. and Oster, H.,
2016.
Circadian clocks, stress, and immunity.
Frontiers in Endocrinology, 7: 37.
ISSN 1664-2392
|
Text
1392742_a1304_Dumbell.pdf - Published version Download (1MB) | Preview |
Abstract
In mammals, molecular circadian clocks are present in most cells of the body, and this circadian network plays an important role in synchronizing physiological processes and behaviors to the appropriate time of day. The hypothalamic–pituitary–adrenal endocrine axis regulates the response to acute and chronic stress, acting through its final effectors – glucocorticoids – released from the adrenal cortex. Glucocorticoid secretion, characterized by its circadian rhythm, has an important role in synchronizing peripheral clocks and rhythms downstream of the master circadian pacemaker in the suprachiasmatic nucleus. Finally, glucocorticoids are powerfully anti-inflammatory, and recent work has implicated the circadian clock in various aspects and cells of the immune system, suggesting a tight interplay of stress and circadian systems in the regulation of immunity. This mini-review summarizes our current understanding of the role of the circadian clock network in both the HPA axis and the immune system, and discusses their interactions.
| Item Type: | Journal article | ||||||
|---|---|---|---|---|---|---|---|
| Publication Title: | Frontiers in Endocrinology | ||||||
| Creators: | Dumbell, R., Matveeva, O. and Oster, H. | ||||||
| Publisher: | Frontiers Media SA | ||||||
| Date: | 2 May 2016 | ||||||
| Volume: | 7 | ||||||
| ISSN: | 1664-2392 | ||||||
| Identifiers: |
|
||||||
| Rights: | Copyright © 2016 Dumbell, Matveeva and Oster. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | ||||||
| Divisions: | Schools > School of Science and Technology | ||||||
| Record created by: | Jeremy Silvester | ||||||
| Date Added: | 09 Dec 2020 11:51 | ||||||
| Last Modified: | 31 May 2021 15:09 | ||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/41825 |
Actions (login required)
 |
Edit View |
Views
Views per month over past year
Downloads
Downloads per month over past year
