Reproducibility of the bronchoconstrictive response to eucapnic voluntary hyperpnoea

Williams, N.C. ORCID: 0000-0002-2607-4572, Johnson, M.A. ORCID: 0000-0002-8226-9438, Hunter, K.A. and Sharpe, G.R., 2015. Reproducibility of the bronchoconstrictive response to eucapnic voluntary hyperpnoea. Respiratory Medicine, 109 (10), pp. 1262-1267. ISSN 0954-6111

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Abstract

Background: Eucapnic voluntary hyperpnoea (EVH) is considered an effective bronchoprovocation challenge for identifying exercise-induced bronchoconstriction (EIB). However, the reproducibility of the hyperpnoea-induced bronchoconstriction (HIB) response elicited by EVH remains unknown and was therefore the focus of this study.

Methods: Two cohorts of 16 physically active males (each cohort comprised 8 controls and 8 with physician diagnosis of asthma) participated in two studies of the short- and long-term reproducibility of the bronchoconstrictive response to an EVH test with dry air. EVH was performed on days 0, 7, 14, and 21 (short-term study), and 0, 35, and 70 (long-term study). HIB was diagnosed by a ≥10% fall in forced expiratory volume in 1 s (FEV1) after EVH.

Results: On day 0 of the short-term study, FEV1 fell by 2 ± 1% (P < 0.05) and 27 ± 18% (P < 0.01) from pre-to post-EVH in control and HIB-positive groups respectively. The post-EVH fall in FEV1 did not differ across the short-term study test days. In the HIB-positive group, the day-to-day coefficient of variation, reproducibility, and smallest meaningful change for the fall in FEV1 were 12%, 328 mL, and 164 mL, respectively. On day 0 of the long-term study, FEV1 fell by 2 ± 2% and 25 ± 18% (P < 0.01) after EVH in control and HIB-positive groups respectively. The post-EVH fall in FEV1 did not differ across the long-term study test days. In the HIB-positive group, the day-to-day coefficient of variation, reproducibility, and smallest meaningful change for the fall in FEV1 were 10%, 196 mL, and 98 mL respectively.

Conclusion: The EVH test elicits a reproducible bronchoconstrictive response in physically active males with physician diagnosed asthma. These data thus support the clinical utility of the EVH test for EIB screening and monitoring.

Item Type: Journal article
Publication Title: Respiratory Medicine
Creators: Williams, N.C., Johnson, M.A., Hunter, K.A. and Sharpe, G.R.
Publisher: Elsevier
Place of Publication: London
Date: October 2015
Volume: 109
Number: 10
ISSN: 0954-6111
Identifiers:
NumberType
10.1016/j.rmed.2015.08.006DOI
Divisions: Schools > School of Science and Technology
Record created by: EPrints Services
Date Added: 09 Oct 2015 09:53
Last Modified: 24 Sep 2019 13:04
URI: http://irep.ntu.ac.uk/id/eprint/4488

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