Reproducibility of the bronchoconstrictive response to eucapnic voluntary hyperpnoea

Williams, NC ORCID: https://orcid.org/0000-0002-2607-4572, Johnson, MA ORCID: https://orcid.org/0000-0002-8226-9438, Hunter, KA ORCID: https://orcid.org/0000-0002-0743-9724 and Sharpe, GR ORCID: https://orcid.org/0000-0002-4575-2332, 2015. Reproducibility of the bronchoconstrictive response to eucapnic voluntary hyperpnoea. Respiratory Medicine, 109 (10), pp. 1262-1267. ISSN 0954-6111

Preview

Text 220733_2634.pdf - Post-print Download (433kB) | Preview

Abstract

Background: Eucapnic voluntary hyperpnoea (EVH) is considered an effective bronchoprovocation challenge for identifying exercise-induced bronchoconstriction (EIB). However, the reproducibility of the hyperpnoea-induced bronchoconstriction (HIB) response elicited by EVH remains unknown and was therefore the focus of this study.

Methods: Two cohorts of 16 physically active males (each cohort comprised 8 controls and 8 with physician diagnosis of asthma) participated in two studies of the short- and long-term reproducibility of the bronchoconstrictive response to an EVH test with dry air. EVH was performed on days 0, 7, 14, and 21 (short-term study), and 0, 35, and 70 (long-term study). HIB was diagnosed by a ≥10% fall in forced expiratory volume in 1 s (FEV1) after EVH.

Results: On day 0 of the short-term study, FEV1 fell by 2 ± 1% (P < 0.05) and 27 ± 18% (P < 0.01) from pre-to post-EVH in control and HIB-positive groups respectively. The post-EVH fall in FEV1 did not differ across the short-term study test days. In the HIB-positive group, the day-to-day coefficient of variation, reproducibility, and smallest meaningful change for the fall in FEV1 were 12%, 328 mL, and 164 mL, respectively. On day 0 of the long-term study, FEV1 fell by 2 ± 2% and 25 ± 18% (P < 0.01) after EVH in control and HIB-positive groups respectively. The post-EVH fall in FEV1 did not differ across the long-term study test days. In the HIB-positive group, the day-to-day coefficient of variation, reproducibility, and smallest meaningful change for the fall in FEV1 were 10%, 196 mL, and 98 mL respectively.

Conclusion: The EVH test elicits a reproducible bronchoconstrictive response in physically active males with physician diagnosed asthma. These data thus support the clinical utility of the EVH test for EIB screening and monitoring.

Item Type:	Journal article
Publication Title:	Respiratory Medicine
Creators:	Williams, N.C., Johnson, M.A., Hunter, K.A. and Sharpe, G.R.
Publisher:	Elsevier
Place of Publication:	London
Date:	October 2015
Volume:	109
Number:	10
ISSN:	0954-6111
Identifiers:	Number Type 10.1016/j.rmed.2015.08.006 DOI
Divisions:	Schools > School of Science and Technology
Record created by:	EPrints Services
Date Added:	09 Oct 2015 09:53
Last Modified:	04 Feb 2022 10:50
URI:	https://irep.ntu.ac.uk/id/eprint/4488

Actions (login required)

Edit View

Statistics

Views

Downloads