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McAuley, A.B.T., Hughes, D.C., Tsaprouni, L.G., Varley, I. 
ORCID: 0000-0002-3607-8921, Suraci, B., Baker, J., Herbert, A.J. and Kelly, A.L.,
2022.
Genetic variations between youth and professional development phase english academy football players.
Genes, 13 (11): 2001.
ISSN 2073-4425
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Abstract
The purpose of this study was to examine differences in the genotype frequency distribution of thirty-three single nucleotide variants (SNVs) between youth development phase (YDP) and professional development phase (PDP) academy football players. One hundred and sixty-six male football players from two Category 1 and Category 3 English academies were examined within their specific age phase: YDP (n = 92; aged 13.84 ± 1.63 years) and PDP (n = 74; aged 18.09 ± 1.51 years). Fisher’s exact tests were used to compare individual genotype frequencies, whereas unweighted and weighted total genotype scores (TGS; TWGS) were computed to assess differences in polygenic profiles. In isolation, the IL6 (rs1800795) G allele was overrepresented in PDP players (90.5%) compared to YDP players (77.2%; p = 0.023), whereby PDP players had nearly three times the odds of possessing a G allele (OR = 2.83, 95% CI: 1.13–7.09). The TGS (p = 0.001) and TWGS (p < 0.001) were significant, but poor, in distinguishing YDP and PDP players (AUC = 0.643–0.694), with PDP players exhibiting an overall more power-orientated polygenic profile. If validated in larger independent youth football cohorts, these findings may have important implications for future studies examining genetic associations in youth football.
| Item Type: | Journal article | ||||||
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| Publication Title: | Genes | ||||||
| Creators: | McAuley, A.B.T., Hughes, D.C., Tsaprouni, L.G., Varley, I., Suraci, B., Baker, J., Herbert, A.J. and Kelly, A.L. | ||||||
| Publisher: | MDPI | ||||||
| Date: | 1 November 2022 | ||||||
| Volume: | 13 | ||||||
| Number: | 11 | ||||||
| ISSN: | 2073-4425 | ||||||
| Identifiers: |
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| Rights: | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | ||||||
| Divisions: | Schools > School of Science and Technology | ||||||
| Record created by: | Jonathan Gallacher | ||||||
| Date Added: | 30 Jan 2023 15:02 | ||||||
| Last Modified: | 30 Jan 2023 15:02 | ||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/48115 |
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