Genetic variations between youth and professional development phase english academy football players

McAuley, ABT, Hughes, DC, Tsaprouni, LG, Varley, I ORCID: https://orcid.org/0000-0002-3607-8921, Suraci, B, Baker, J, Herbert, AJ and Kelly, AL, 2022. Genetic variations between youth and professional development phase english academy football players. Genes, 13 (11): 2001. ISSN 2073-4425

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Abstract

The purpose of this study was to examine differences in the genotype frequency distribution of thirty-three single nucleotide variants (SNVs) between youth development phase (YDP) and professional development phase (PDP) academy football players. One hundred and sixty-six male football players from two Category 1 and Category 3 English academies were examined within their specific age phase: YDP (n = 92; aged 13.84 ± 1.63 years) and PDP (n = 74; aged 18.09 ± 1.51 years). Fisher’s exact tests were used to compare individual genotype frequencies, whereas unweighted and weighted total genotype scores (TGS; TWGS) were computed to assess differences in polygenic profiles. In isolation, the IL6 (rs1800795) G allele was overrepresented in PDP players (90.5%) compared to YDP players (77.2%; p = 0.023), whereby PDP players had nearly three times the odds of possessing a G allele (OR = 2.83, 95% CI: 1.13–7.09). The TGS (p = 0.001) and TWGS (p < 0.001) were significant, but poor, in distinguishing YDP and PDP players (AUC = 0.643–0.694), with PDP players exhibiting an overall more power-orientated polygenic profile. If validated in larger independent youth football cohorts, these findings may have important implications for future studies examining genetic associations in youth football.

Item Type:	Journal article
Publication Title:	Genes
Creators:	McAuley, A.B.T., Hughes, D.C., Tsaprouni, L.G., Varley, I., Suraci, B., Baker, J., Herbert, A.J. and Kelly, A.L.
Publisher:	MDPI
Date:	1 November 2022
Volume:	13
Number:	11
ISSN:	2073-4425
Identifiers:	Number Type 10.3390/genes13112001 DOI 1639320 Other
Rights:	© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Divisions:	Schools > School of Science and Technology
Record created by:	Jonathan Gallacher
Date Added:	30 Jan 2023 15:02
Last Modified:	30 Jan 2023 15:02
URI:	https://irep.ntu.ac.uk/id/eprint/48115

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