The Kornblum DeLaMare rearrangement in natural product synthesis: 25 years of innovation

Kimber, MC and Lee, DS ORCID: https://orcid.org/0000-0002-8288-1838, 2024. The Kornblum DeLaMare rearrangement in natural product synthesis: 25 years of innovation. Natural Product Reports. ISSN 0265-0568

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Abstract

Since its initial disclosure in 1951, the Kornblum DeLaMare rearrangement has proved an important synthetic transformation and has been widely adopted as a biomimetic step in natural product synthesis. Utilising the base catalysed decomposition of alkyl peroxides to yield a ketone and alcohol has found use in many syntheses as well as a key strategic step, including the unmasking of furans, as a biomimetic synthetic tool, and the use of the rearrangement to install oxygen enantioselectively. Since ca. 1998, its impact as a synthetic transformation has grown significantly, especially given the frequency of use in natural product syntheses, therefore this 25 year time period will be the focus of the review.

Item Type:	Journal article
Publication Title:	Natural Product Reports
Creators:	Kimber, M.C. and Lee, D.S.
Publisher:	Royal Society of Chemistry (RSC)
Date:	31 January 2024
ISSN:	0265-0568
Identifiers:	Number Type 10.1039/d3np00058c DOI 1865568 Other
Divisions:	Schools > School of Science and Technology
Record created by:	Jeremy Silvester
Date Added:	22 Feb 2024 09:44
Last Modified:	22 Feb 2024 09:44
URI:	https://irep.ntu.ac.uk/id/eprint/50915

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