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Al Shuhoumi, M.A., Al Waili, A. and Turner, M.D. 
ORCID: 0000-0001-7175-1053,
2023.
Life and maladies in the grey area between the up & down regulation of GATA6: uncharted spots of beta-pancreatic islet cells.
International Journal of Clinical Biochemistry and Research, 10 (4), pp. 302-313.
ISSN 2394-6369
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Abstract
Death and dysfunctionality of pancreatic islet beta-cells are a centric key element in the pathogenesis of type 2 diabetes mellitus (T2DM). Saturated fatty acids are commonly circulated in diabetic and obese individuals. Elevated and chronic exposure to fatty acids has a pernicious influence on islet cells’ functionality and survival due to its capability to induce apoptosis and endoplasmic reticulum (ER) stress. However, T2DM is a heterogeneous disorder that includes genetic and environmental factors in conjunction with dyslipidaemia with a considerably high rate of morbidity and mortality. There are many genes involved in the pathogenesis that remain to be charted. Here, we show a comprehensive interrogation of GATA6 based on previously published gene expression data on the basis of stating its validity via bioinformatics analysis and reaching a new understanding. Various datasets with different patient cohorts were compared and contrasted. Gene ontology and predictive pathway analysis (e.g., Kyoto Encyclopaedia of Genes and Genomes pathway; KEGG) were used to explore interactions of numerous differentially expressed genes. Protein-protein interactions network through the STRING database has appreciated a list of key genes. GATA6 interacted with genes from pathways that were significantly enriched.
| Item Type: | Journal article | ||||||
|---|---|---|---|---|---|---|---|
| Publication Title: | International Journal of Clinical Biochemistry and Research | ||||||
| Creators: | Al Shuhoumi, M.A., Al Waili, A. and Turner, M.D. | ||||||
| Publisher: | IP Innovative Publication Pvt Ltd | ||||||
| Date: | 2023 | ||||||
| Volume: | 10 | ||||||
| Number: | 4 | ||||||
| ISSN: | 2394-6369 | ||||||
| Identifiers: |
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| Rights: | © 2023 author(s), Published by Innovative Publication. This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. | ||||||
| Divisions: | Schools > School of Science and Technology | ||||||
| Record created by: | Jonathan Gallacher | ||||||
| Date Added: | 27 Aug 2024 08:20 | ||||||
| Last Modified: | 27 Aug 2024 08:20 | ||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/52087 |
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