Life and maladies in the grey area between the up & down regulation of GATA6: uncharted spots of beta-pancreatic islet cells

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Al Shuhoumi, MA, Al Waili, A and Turner, MD ORCID: https://orcid.org/0000-0001-7175-1053, 2023. Life and maladies in the grey area between the up & down regulation of GATA6: uncharted spots of beta-pancreatic islet cells. International Journal of Clinical Biochemistry and Research, 10 (4), pp. 302-313. ISSN 2394-6369

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Official URL: https://doi.org/10.18231/j.ijcbr.2023.055

Abstract

Death and dysfunctionality of pancreatic islet beta-cells are a centric key element in the pathogenesis of type 2 diabetes mellitus (T2DM). Saturated fatty acids are commonly circulated in diabetic and obese individuals. Elevated and chronic exposure to fatty acids has a pernicious influence on islet cells’ functionality and survival due to its capability to induce apoptosis and endoplasmic reticulum (ER) stress. However, T2DM is a heterogeneous disorder that includes genetic and environmental factors in conjunction with dyslipidaemia with a considerably high rate of morbidity and mortality. There are many genes involved in the pathogenesis that remain to be charted. Here, we show a comprehensive interrogation of GATA6 based on previously published gene expression data on the basis of stating its validity via bioinformatics analysis and reaching a new understanding. Various datasets with different patient cohorts were compared and contrasted. Gene ontology and predictive pathway analysis (e.g., Kyoto Encyclopaedia of Genes and Genomes pathway; KEGG) were used to explore interactions of numerous differentially expressed genes. Protein-protein interactions network through the STRING database has appreciated a list of key genes. GATA6 interacted with genes from pathways that were significantly enriched.

Item Type:	Journal article
Publication Title:	International Journal of Clinical Biochemistry and Research
Creators:	Al Shuhoumi, M.A., Al Waili, A. and Turner, M.D.
Publisher:	IP Innovative Publication Pvt Ltd
Date:	2023
Volume:	10
Number:	4
ISSN:	2394-6369
Identifiers:	Number Type 10.18231/j.ijcbr.2023.055 DOI 2199092 Other
Rights:	© 2023 author(s), Published by Innovative Publication. This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
Divisions:	Schools > School of Science and Technology
Record created by:	Jonathan Gallacher
Date Added:	27 Aug 2024 08:20
Last Modified:	27 Aug 2024 08:20
URI:	https://irep.ntu.ac.uk/id/eprint/52087